Document Detail


Interleukin-1-mediated diseases.
MedLine Citation:
PMID:  23460390     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Interleukin-1 (IL-1)-mediated diseases are caused by an inappropriately high production and release of IL-1 beta which results in a multitude of symptoms, e.g. arthritis, exanthema, conjunctivitis, serositis, fever and loss of hearing. If IL-1-mediated diseases remain unrecognized or are recognized and treated too late, long-term complications, such as amyloidosis may occur. In recent years the diagnostic and therapeutic options with respect to IL-1-mediated diseases have drastically improved. These diseases often manifesting in childhood can now be treated with monoclonal antibodies against IL-1 or with IL-1 receptor antagonists. Increased IL-1 secretion does not only play a role in relatively rare hereditary diseases, such as cryopyrin-associated periodic fever syndromes or familial Mediterranean fever but also in widespread diseases, such as gout or type 2 diabetes. This article will focus on pathogenic, diagnostic and therapeutic aspects of IL-1-mediated inflammatory diseases.
Authors:
D Holzinger; H Becker; A M Jacobi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-6
Journal Detail:
Title:  Der Internist     Volume:  -     ISSN:  1432-1289     ISO Abbreviation:  Internist (Berl)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0264620     Medline TA:  Internist (Berl)     Country:  -    
Other Details:
Languages:  GER     Pagination:  -     Citation Subset:  -    
Affiliation:
Institut für Immunologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus A1, 48149, Münster, Deutschland.
Vernacular Title:
Interleukin-1-vermittelte Erkrankungen.
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