Document Detail

Interleukin-1 inhibits the secretion of gastric acid in rats: possible involvement of prostaglandin.
MedLine Citation:
PMID:  2788416     Owner:  NLM     Status:  MEDLINE    
To examine the hypothesis that interleukin-1 may inhibit the secretion of gastric acid, the present study was carried out using pylorusligated rats. Based upon three lines of evidence, we report here that interleukin-1, both endogenously released and exogenously administered, suppresses gastric acid secretion and that the interleukin-1-induced inhibition of acid output is possibly mediated by prostaglandin. First, lipopolysaccharide, a potent stimulant of the release and production of endogenous interleukin-1, caused the suppression of gastric acid, and this response was dose-related. Second, the intraperitoneal injection of interleukin-1 resulted in a dose-related inhibition of gastric acid output. Third, the administration of indomethacin completely blocked the suppression of gastric acid secretion induced by interleukin-1. These results demonstrated for the first time that IL-1 might be involved in the regulation of gastric secretion.
A Uehara; T Okumura; C Sekiya; K Okamura; Y Takasugi; M Namiki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  162     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-09-21     Completed Date:  1989-09-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1578-84     Citation Subset:  IM    
Department of Internal Medicine (III), Asahikawa Medical College, Hokkaido, Japan.
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MeSH Terms
Corticotropin-Releasing Hormone / physiology
Dose-Response Relationship, Drug
Gastric Juice / secretion*
Gastric Mucosa / secretion
Indomethacin / pharmacology
Interleukin-1 / pharmacology*
Lipopolysaccharides / pharmacology
Prostaglandins / physiology
Rats, Inbred Strains
Secretory Rate / drug effects
Reg. No./Substance:
0/Interleukin-1; 0/Lipopolysaccharides; 0/Prostaglandins; 53-86-1/Indomethacin; 9015-71-8/Corticotropin-Releasing Hormone

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