| Interleukin-1 inhibits the secretion of gastric acid in rats: possible involvement of prostaglandin. | |
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MedLine Citation:
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PMID: 2788416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the hypothesis that interleukin-1 may inhibit the secretion of gastric acid, the present study was carried out using pylorusligated rats. Based upon three lines of evidence, we report here that interleukin-1, both endogenously released and exogenously administered, suppresses gastric acid secretion and that the interleukin-1-induced inhibition of acid output is possibly mediated by prostaglandin. First, lipopolysaccharide, a potent stimulant of the release and production of endogenous interleukin-1, caused the suppression of gastric acid, and this response was dose-related. Second, the intraperitoneal injection of interleukin-1 resulted in a dose-related inhibition of gastric acid output. Third, the administration of indomethacin completely blocked the suppression of gastric acid secretion induced by interleukin-1. These results demonstrated for the first time that IL-1 might be involved in the regulation of gastric secretion. |
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Authors:
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A Uehara; T Okumura; C Sekiya; K Okamura; Y Takasugi; M Namiki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 162 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-21 Completed Date: 1989-09-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1578-84 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine (III), Asahikawa Medical College, Hokkaido, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corticotropin-Releasing Hormone / physiology Dose-Response Relationship, Drug Gastric Juice / secretion* Gastric Mucosa / secretion Indomethacin / pharmacology Interleukin-1 / pharmacology* Lipopolysaccharides / pharmacology Male Prostaglandins / physiology Rats Rats, Inbred Strains Secretory Rate / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Lipopolysaccharides; 0/Prostaglandins; 53-86-1/Indomethacin; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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