Document Detail

Interleukin-1 induces c-fos and c-jun gene expression in T helper type II cells through different signal transmission pathways.
MedLine Citation:
PMID:  1322303     Owner:  NLM     Status:  MEDLINE    
Interleukin (IL)-1 induces proliferation and expression of several protooncogenes in the T helper 2 cell line D10A. We have analyzed the signal transmission pathways activated by IL-1 in these cells, leading to the expression of c-jun and c-fos. IL-1 induced c-jun gene transcription and mRNA expression by means of a pathway dependent on protein tyrosine kinase activity since tyrphostin, a specific inhibitor of tyrosine kinase, inhibited this induction. This mechanism of transmission signaling was independent of protein kinase C (PKC) and was linked to the 80-kDa IL-1 receptor (IL-1R). In addition, phorbol esters did not induce c-jun mRNA expression, whereas c-fos mRNA expression mediated by IL-1 dependent on PKC; this pathway was linked to a different, still unidentified IL-1R that was functional in the D10A cell line. Accumulation of intracellular cAMP generated by IL-1 through the 80-kDa IL-1R negatively regulated c-fos expression which was induced by IL-1 through PKC activation. We conclude that IL-1 modulates the expression of c-fos in D10A cells by occupying of two independent IL-1R that are linked to different signal transduction pathways.
E Muñoz; A M Zubiaga; B T Huber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of immunology     Volume:  22     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-01     Completed Date:  1992-09-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  2101-6     Citation Subset:  IM    
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina de Córdoba, Spain.
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MeSH Terms
Cyclic AMP / physiology
Gene Expression Regulation / drug effects*
Genes, fos*
Genes, jun*
Interleukin-1 / pharmacology*
Isoquinolines / pharmacology
Protein Kinase C / physiology
Protein-Tyrosine Kinases / analysis
RNA, Messenger / analysis
Signal Transduction*
T-Lymphocytes, Helper-Inducer / physiology*
Grant Support
Reg. No./Substance:
0/Interleukin-1; 0/Isoquinolines; 0/RNA, Messenger; 60-92-4/Cyclic AMP; 84478-11-5/N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide; EC Kinases; EC Kinase C

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