Document Detail

Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1.
MedLine Citation:
PMID:  2799385     Owner:  NLM     Status:  MEDLINE    
Interleukin-1 (IL-1) is a major regulator of inflammation and immunity. IL-1 induces T lymphocyte growth by acting as a second signal (together with antigen) in enhancing the production of interleukin-2 (IL-2). An IL-1-responsive element in the promoter region of the human IL-2 gene was similar to the binding site for the transcription factor AP-1. IL-1 enhanced expression of c-jun messenger RNA, whereas the antigenic signal enhanced messenger RNA expression of c-fos. Thus, the two components of the AP-1 factor are independently regulated and the AP-1 factor may serve as a nuclear mediator for the many actions of IL-1 on cells.
K Muegge; T M Williams; J Kant; M Karin; R Chiu; A Schmidt; U Siebenlist; H A Young; S K Durum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  246     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-08     Completed Date:  1989-11-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-51     Citation Subset:  IM    
Laboratory of Molecular Immunoregulation, Program Resources Inc., Frederick, MD 21701.
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MeSH Terms
Chloramphenicol O-Acetyltransferase / genetics
Gene Expression Regulation
Interleukin-1 / physiology*
Interleukin-2 / genetics*
Promoter Regions, Genetic / genetics
Proto-Oncogene Proteins c-jun / genetics*
Tetradecanoylphorbol Acetate / pharmacology
Tumor Cells, Cultured
Grant Support
5-T32-CA-09140/CA/NCI NIH HHS; AI-R01-23879/AI/NIAID NIH HHS
Reg. No./Substance:
0/Interleukin-1; 0/Interleukin-2; 0/Proto-Oncogene Proteins c-jun; 16561-29-8/Tetradecanoylphorbol Acetate; EC O-Acetyltransferase

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