| Interleukin-1 resets glucose homeostasis at central and peripheral levels: relevance for immunoregulation. | |
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MedLine Citation:
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PMID: 20134186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We briefly discuss here evidence showing that the capacity of IL-1beta to mediate adjustments of glucose homeostasis can be added to the already well-known pleiotropic effects of this cytokine. Such adjustments, which are necessary for satisfying the high energetic demands of immune/inflammatory responses, can be mediated by effects of endogenous IL-1 exerted at peripheral and brain levels in a concerted action with other cytokines and neuroendocrine mechanisms. |
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Authors:
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Hugo O Besedovsky; Adriana Del Rey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-02-04 |
Journal Detail:
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Title: Neuroimmunomodulation Volume: 17 ISSN: 1423-0216 ISO Abbreviation: Neuroimmunomodulation Publication Date: 2010 |
Date Detail:
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Created Date: 2010-02-05 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422763 Medline TA: Neuroimmunomodulation Country: Switzerland |
Other Details:
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Languages: eng Pagination: 139-41 Citation Subset: IM |
Copyright Information:
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Copyright 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Immunophysiology, Institute of Physiology and Pathophysiology, Medical Faculty, Marburg, Germany. besedovs@mailer.uni-marburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Energy Metabolism / immunology* Glucose / metabolism* Glucose Transporter Type 4 / metabolism Homeostasis / immunology Humans Immune System / physiology Insulin / metabolism, secretion Interleukin-1beta / metabolism* Neuroimmunomodulation / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Glucose Transporter Type 4; 0/Interleukin-1beta; 11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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