| Interkingdom crosstalk: host neuroendocrine stress hormones drive the hemolytic behavior of Salmonella typhi. | |
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MedLine Citation:
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PMID: 21758008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of bacterial pathogens to sense their immediate environment plays a significant role on their capacity to survive and cause disease. Salmonella enterica serovar typhi (S. typhi) is an exclusively human pathogen that causes typhoid fever. In a recent study, we have shown that S. typhi senses and responds to host neuroendocrine stress hormones to release the toxin hemolysin E. Hormone-mediated hemolysis by S. typhi was inhibited by the β-blocker propranolol and was dependent on the presence of the CpxAR signal transduction system. Furthermore, we demonstrate that normal expression of the small RNA micA is necessary for the arbitration of the response to host neuroendocrine hormones. This leads to a significant decrease in the levels of the outer membrane protein OmpA and increased formation of membrane vesicles containing HlyE. The exploration of host pathogen interactions is of paramount importance in deciphering pathogen virulence and the discovery of novel treatments. |
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Authors:
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Michail H Karavolos; Paul Williams; C M Anjam Khan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-07-01 |
Journal Detail:
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Title: Virulence Volume: 2 ISSN: 2150-5608 ISO Abbreviation: Virulence Publication Date: 2011 Jul-Aug |
Date Detail:
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Created Date: 2011-08-17 Completed Date: 2011-12-15 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 101531386 Medline TA: Virulence Country: United States |
Other Details:
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Languages: eng Pagination: 371-4 Citation Subset: IM |
Affiliation:
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Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle, UK. michail.karavolos@ncl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Proteins / genetics, metabolism* Hemolysin Proteins / genetics, metabolism* Hormones / metabolism* Host-Pathogen Interactions* Humans Neurosecretory Systems / metabolism* Salmonella typhi / genetics, metabolism, pathogenicity* Typhoid Fever / metabolism*, microbiology Virulence |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Hemolysin Proteins; 0/Hormones |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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