| Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer. | |
| | |
MedLine Citation:
|
PMID: 20155787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: To address issues regarding the fractionation of radiotherapy (RT) and timing of surgery for rectal cancer, a multicentre trial has randomized patients to preoperative short-course RT with two different intervals to surgery, or long-course RT with delayed surgery. The present interim analysis assessed feasibility, compliance and complications after RT and surgery. METHODS: Some 303 patients were randomized to either short-course RT (5 x 5 Gy) and surgery within 1 week (group 1), short-course RT and surgery after 4-8 weeks (group 2) or long-course RT (25 x 2 Gy) and surgery after 4-8 weeks (group 3). RESULTS: Demographic data were similar between groups and there were few protocol violations (5.0-6 per cent). Eight patients (2.6 per cent) developed radiation-induced acute toxicity. There were no significant differences in postoperative complications between groups (46.6, 40.0 and 32 per cent in groups 1, 2 and 3 respectively; P = 0.164). Patients receiving short-course RT with surgery 11-17 days after the start of RT had the highest complication rate (24 of 37). CONCLUSION: Compliance was acceptable and severe acute toxicity was low, irrespective of fractionation. Short-course RT with immediate surgery had a tendency towards more postoperative complications, but only if surgery was delayed beyond 10 days after the start of RT. Registration number: NCT00904813 (http://www.clinicaltrials.gov). |
| | |
Authors:
|
D Pettersson; B Cedermark; T Holm; C Radu; L P?hlman; B Glimelius; A Martling |
Related Documents
:
|
486907 - The management of gross refractory obesity by jejuno-ileal bypass. 3046167 - Primary megaureter in the neonate with prenatal or postnatal diagnosis. 1946927 - Rheumatoid arthritis: workload and outcome over 10 years. 4041727 - The role of surgical local excision in the treatment of rectal cancer. 10330387 - Atrial pacing periablation for prevention of paroxysmal atrial fibrillation. 17443517 - Intravenous magnesium for acute myocardial infarction. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The British journal of surgery Volume: 97 ISSN: 1365-2168 ISO Abbreviation: Br J Surg Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-03-10 Completed Date: 2010-03-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: England |
Other Details:
|
Languages: eng Pagination: 580-7 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00904813 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Combined Modality Therapy Feasibility Studies Female Follow-Up Studies Humans Male Middle Aged Postoperative Complications / etiology* Preoperative Care / methods* Rectal Neoplasms / radiotherapy*, surgery Reoperation Time Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach.
Next Document: Randomized controlled trial of pelvic calcium alginate following rectal cancer surgery.