Document Detail

Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer.
MedLine Citation:
PMID:  20155787     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To address issues regarding the fractionation of radiotherapy (RT) and timing of surgery for rectal cancer, a multicentre trial has randomized patients to preoperative short-course RT with two different intervals to surgery, or long-course RT with delayed surgery. The present interim analysis assessed feasibility, compliance and complications after RT and surgery.
METHODS: Some 303 patients were randomized to either short-course RT (5 x 5 Gy) and surgery within 1 week (group 1), short-course RT and surgery after 4-8 weeks (group 2) or long-course RT (25 x 2 Gy) and surgery after 4-8 weeks (group 3).
RESULTS: Demographic data were similar between groups and there were few protocol violations (5.0-6 per cent). Eight patients (2.6 per cent) developed radiation-induced acute toxicity. There were no significant differences in postoperative complications between groups (46.6, 40.0 and 32 per cent in groups 1, 2 and 3 respectively; P = 0.164). Patients receiving short-course RT with surgery 11-17 days after the start of RT had the highest complication rate (24 of 37).
CONCLUSION: Compliance was acceptable and severe acute toxicity was low, irrespective of fractionation. Short-course RT with immediate surgery had a tendency towards more postoperative complications, but only if surgery was delayed beyond 10 days after the start of RT.
D Pettersson; B Cedermark; T Holm; C Radu; L Påhlman; B Glimelius; A Martling
Related Documents :
9655097 - Distraction osteogenesis of the lower extremity with use of monolateral external fixati...
17058317 - Intrahepatic cholangiojejunostomy following hepatobiliary resection.
1201457 - Subjective side-effects of ect.
11491047 - Scabies management in the community.
14551277 - Flared polyurethane-covered self-expandable nitinol stent for malignant biliary obstruc...
17670707 - Is short-term anticoagulation necessary after mitral valve repair?
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  97     ISSN:  1365-2168     ISO Abbreviation:  Br J Surg     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-03-31     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  580-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Data Bank Information
Bank Name/Acc. No.:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Combined Modality Therapy
Feasibility Studies
Follow-Up Studies
Middle Aged
Postoperative Complications / etiology*
Preoperative Care / methods*
Rectal Neoplasms / radiotherapy*,  surgery
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach.
Next Document:  Randomized controlled trial of pelvic calcium alginate following rectal cancer surgery.