Document Detail

Interictal hyperperfusion observed in infants with cortical dysgenesis.
MedLine Citation:
PMID:  10487475     Owner:  NLM     Status:  MEDLINE    
We investigated increases of interictal regional cerebral blood flow (rCBF) in patients with intractable epilepsy caused by cortical dysgenesis. Using single photon emission computed tomography, we measured interictal rCBF of epileptic foci in 24 patients with cortical dysgenesis who achieved Engel Class I or II outcomes at least 1 year after surgical intervention. The patients included 14 males and ten females, ranging in age from 2 months to 34 years (mean 6 years and 5 months). In the interictal period, dysplastic areas showed hyperperfusion in four patients (17%), hypoperfusion in 15 (62%), and isoperfusion patterns in five (21%). Interictal hyperperfusion was found in four infants aged 3-4 months; three with focal cortical dysplasia and one with hemimegalencephaly. Our results suggest that interictal hyperperfusion may indicate the presence of an active epileptic focus in infants with cortical dysgenesis, but not in older children or adults with the same disorder. Given the risk of misinterpreting the normal side as hypoperfused, the phenomenon of interictal hyperperfusion in the epileptogenic area should be taken into account when diagnosing pediatric epilepsy caused by cortical dysgenesis.
T Maehara; H Shimizu; A Yagishita; N Kaito; M Oda; N Arai
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Brain & development     Volume:  21     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-19     Completed Date:  1999-10-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  407-12     Citation Subset:  IM    
Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital, Japan.
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MeSH Terms
Aging / physiology
Brain Diseases / congenital,  physiopathology*,  radionuclide imaging
Cerebral Cortex / abnormalities*,  radionuclide imaging
Cerebrovascular Circulation / physiology*
Child, Preschool
Nervous System Malformations / physiopathology*,  radionuclide imaging
Seizures / congenital,  physiopathology*,  radionuclide imaging
Tomography, Emission-Computed, Single-Photon

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