Document Detail


Interictal SPECT in patients with mesial temporal lobe epilepsy and psychosis: a case-control study.
MedLine Citation:
PMID:  15708303     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Psychosis is commonly observed in patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS). Interictal single photon emission computed tomography (SPECT) was performed to compare regional cerebral blood flow (rCBF) pattern of MTLE-HS patients with psychosis of epilepsy (POE) comorbidity and MTLE-HS patients without any psychiatric disorders (Control group). For this, 21 patients with POE and 23 Control patients were matched by educational level, clinical, demographic, electrophysiological, and MRI data. SPECT scans were acquired using (99m)Tc and interpreted with a semiquantitative method. We analyzed brain regions of interest (ROI) of frontal, temporal, and parietal cortex, in addition to subcortical structures. There were no significant statistical differences of ROI between the POE group and the Control group after Bonferroni adjustment. However, we observed a trend for rCBF increase of right posterior cingulate in the POE Group. This increase would be in accordance with recent findings of cingulate abnormalities in schizophrenia, suggesting that abnormal function in this region might be associated with the psychotic phenomena.
Authors:
Ricardo Guarnieri; Lauro Wichert-Ana; Jaime E C Hallak; Tonicarlo R Velasco; Roger Walz; Mery Kato; Veriano Alexandre; Vera C Terra-Bustamante; Marino M Bianchin; Antonio W Zuardi; John F W Deakin; Américo C Sakamoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry research     Volume:  138     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-14     Completed Date:  2005-04-26     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  75-84     Citation Subset:  IM    
Affiliation:
Center for Epilepsy Surgery-CIREP, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, CEP 14.048-900, Ribeirão Preto, SP, Brazil. ricardoguarnieri@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Cerebrovascular Circulation*
Comorbidity
Epilepsy, Temporal Lobe / diagnosis,  epidemiology,  physiopathology*
Female
Frontal Lobe / anatomy & histology,  blood supply,  physiopathology
Functional Laterality / physiology
Gyrus Cinguli / anatomy & histology,  blood supply,  physiopathology
Humans
Magnetic Resonance Imaging
Male
Parietal Lobe / anatomy & histology,  blood supply,  physiopathology
Preoperative Care
Psychotic Disorders / diagnosis,  epidemiology,  physiopathology*
Regional Blood Flow / physiology
Schizophrenia / diagnosis,  epidemiology,  physiopathology*
Temporal Lobe / anatomy & histology,  blood supply,  physiopathology
Tomography, Emission-Computed, Single-Photon*

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