Document Detail

Interhemispheric hypoconnectivity in schizophrenia: fiber integrity and volume differences of the corpus callosum in patients and unaffected relatives.
MedLine Citation:
PMID:  21964509     Owner:  NLM     Status:  MEDLINE    
Changes in hemispheric asymmetry and inter-hemispheric connectivity have been reported in schizophrenia. However, the genetic contribution to these alterations is still unclear. In the current study, we applied an automatic segmentation method to structural MRI and diffusion tensor imaging (DTI) data and examined volume and fiber integrity of the corpus callosum (CC), the main interhemispheric fiber tract, in 16 chronic schizophrenia (SZ) patients, matched first degree relatives and controls. SZ patients and relatives had smaller CC volumes than controls, particularly in the posterior genu, isthmus and splenium. Fractional anisotropy (FA), an indicator of fiber integrity, was reduced in patients and relatives in the whole CC, the inferior genu, the superior genu and the isthmus. Correspondingly, the mean diffusivity (MD) values of the whole CC and the isthmus were higher in patients and their unaffected relatives, indicating decreased compactness and increased intercellular space. Relatives had intermediate values in the volumetric and fiber integrity measurements between patients and controls. Lower CC volume and fiber integrity in SZ patients were associated with more severe auditory hallucinations. These results support the connectivity hypothesis of SZ (Friston, 1998) and particularly highlight the altered interhemispheric connectivity, which appears to be a genetic feature of SZ risk.
Christian Knöchel; Viola Oertel-Knöchel; Ralf Schönmeyer; Anna Rotarska-Jagiela; Vincent van de Ven; David Prvulovic; Corinna Haenschel; Peter Uhlhaas; Johannes Pantel; Harald Hampel; David E J Linden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-26
Journal Detail:
Title:  NeuroImage     Volume:  59     ISSN:  1095-9572     ISO Abbreviation:  Neuroimage     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-05     Completed Date:  2012-04-17     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  926-34     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Aged, 80 and over
Cerebrum / pathology*
Corpus Callosum / pathology*
Diffusion Tensor Imaging / methods*
Genetic Predisposition to Disease / genetics*
Imaging, Three-Dimensional
Middle Aged
Nerve Fibers, Myelinated / pathology*
Neural Pathways / pathology
Organ Size
Risk Assessment
Schizophrenia / genetics*,  pathology*
Grant Support
088130//Wellcome Trust

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