Document Detail

Intergenic recombination with HLA-C leads to a novel HLA-A*19 allele, HLA-A*2910, that is characterized by a functionally inactive amino acid exchange in the loop connecting the alpha and alpha domains.
MedLine Citation:
PMID:  16451207     Owner:  NLM     Status:  MEDLINE    
This report describes the HLA-A*29 allele (A*2910) that has been identified by sequence-based typing in an 8-year-old Turkish female with leukaemia during search for a family-related stem cell donor. The allele is characterized by a nucleotide substitution (Guanine to Adenine) in exon 3 at position 258, leading to an amino acid exchange from glutamic acid to lysine at position 177. From family analysis and sequence comparison, the HLA-A*2910 allele has arisen from intergenic recombination with HLA-C. Structurally, the amino acid exchange at position 177 is probably functionally inactive due to the location of this amino acid exchange in the loop connecting the alpha(2) and alpha(3) domains.
M Mosebach; V Brixner; P Bader; T H Klingebiel; E Seifried; C Seidl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  67     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-02     Completed Date:  2006-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  75-8     Citation Subset:  IM    
Department of Transplantation Immunology and Immunogenetics, Institute of Transfusion Medicine and Immunohematology, Red Cross Blood Donor Service, Baden-Württemberg - Hessen, Frankfurt am Main, Germany.
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MeSH Terms
Amino Acid Sequence
Amino Acid Substitution
Base Sequence
HLA-A Antigens / genetics*
HLA-C Antigens / genetics*
Molecular Sequence Data
Protein Structure, Tertiary
Recombination, Genetic*
Reg. No./Substance:
0/HLA-A Antigens; 0/HLA-A*2910 antigen; 0/HLA-A19; 0/HLA-C Antigens

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