| Intergenic recombination with HLA-C leads to a novel HLA-A*19 allele, HLA-A*2910, that is characterized by a functionally inactive amino acid exchange in the loop connecting the alpha and alpha domains. | |
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MedLine Citation:
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PMID: 16451207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report describes the HLA-A*29 allele (A*2910) that has been identified by sequence-based typing in an 8-year-old Turkish female with leukaemia during search for a family-related stem cell donor. The allele is characterized by a nucleotide substitution (Guanine to Adenine) in exon 3 at position 258, leading to an amino acid exchange from glutamic acid to lysine at position 177. From family analysis and sequence comparison, the HLA-A*2910 allele has arisen from intergenic recombination with HLA-C. Structurally, the amino acid exchange at position 177 is probably functionally inactive due to the location of this amino acid exchange in the loop connecting the alpha(2) and alpha(3) domains. |
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Authors:
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M Mosebach; V Brixner; P Bader; T H Klingebiel; E Seifried; C Seidl |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Tissue antigens Volume: 67 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-02-02 Completed Date: 2006-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: Denmark |
Other Details:
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Languages: eng Pagination: 75-8 Citation Subset: IM |
Affiliation:
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Department of Transplantation Immunology and Immunogenetics, Institute of Transfusion Medicine and Immunohematology, Red Cross Blood Donor Service, Baden-Württemberg - Hessen, Frankfurt am Main, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles* Amino Acid Sequence Amino Acid Substitution Base Sequence Child Exons Female HLA-A Antigens / genetics* HLA-C Antigens / genetics* Humans Molecular Sequence Data Protein Structure, Tertiary Recombination, Genetic* Turkey |
| Chemical | |
Reg. No./Substance:
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0/HLA-A Antigens; 0/HLA-A*2910 antigen; 0/HLA-A19; 0/HLA-C Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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