Document Detail


Intergenic recombination with HLA-C leads to a novel HLA-A*19 allele, HLA-A*2910, that is characterized by a functionally inactive amino acid exchange in the loop connecting the alpha and alpha domains.
MedLine Citation:
PMID:  16451207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report describes the HLA-A*29 allele (A*2910) that has been identified by sequence-based typing in an 8-year-old Turkish female with leukaemia during search for a family-related stem cell donor. The allele is characterized by a nucleotide substitution (Guanine to Adenine) in exon 3 at position 258, leading to an amino acid exchange from glutamic acid to lysine at position 177. From family analysis and sequence comparison, the HLA-A*2910 allele has arisen from intergenic recombination with HLA-C. Structurally, the amino acid exchange at position 177 is probably functionally inactive due to the location of this amino acid exchange in the loop connecting the alpha(2) and alpha(3) domains.
Authors:
M Mosebach; V Brixner; P Bader; T H Klingebiel; E Seifried; C Seidl
Related Documents :
24185787 - Cryopreservation of embryogenic tissue of sweet potato (ipomoea batatas): use of sucros...
1643287 - Isolation and characterization of a cdna clone encoding the tata box-binding protein (t...
15129327 - Zebrafish cdna encoding multifunctional fatty acid elongase involved in production of e...
1387367 - Lys-373 of actin is involved in binding to caldesmon.
654927 - Competitive inhibition and exchange transport between arginine and lysine in the proces...
9569807 - Effect of various demineralizing agents on mineral contents of cementum surfaces (an el...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  67     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-02     Completed Date:  2006-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  75-8     Citation Subset:  IM    
Affiliation:
Department of Transplantation Immunology and Immunogenetics, Institute of Transfusion Medicine and Immunohematology, Red Cross Blood Donor Service, Baden-Württemberg - Hessen, Frankfurt am Main, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alleles*
Amino Acid Sequence
Amino Acid Substitution
Base Sequence
Child
Exons
Female
HLA-A Antigens / genetics*
HLA-C Antigens / genetics*
Humans
Molecular Sequence Data
Protein Structure, Tertiary
Recombination, Genetic*
Turkey
Chemical
Reg. No./Substance:
0/HLA-A Antigens; 0/HLA-A*2910 antigen; 0/HLA-A19; 0/HLA-C Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Generation of the B*41 group of alleles as indicated by intron sequences.
Next Document:  The association between HLA class II haplotype with Graves' disease in Thai population.