| Intergenerational programming of impaired nephrogenesis and hypertension in rats following maternal protein restriction during pregnancy. | |
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MedLine Citation:
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PMID: 18778527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Associations between birth weight and CVD in adult life are supported by experiments showing that undernutrition in fetal life programmes blood pressure. In rats, the feeding of a maternal low-protein (MLP) diet during gestation programmes hypertension. The present study aimed to assess the potential for a nutritional insult to impact across several generations. Pregnant female Wistar (F0) rats were fed a control (CON; n 10) or MLP (n 10) diet throughout gestation. At delivery all animals were fed a standard laboratory chow diet. At 10 weeks of age, F1 generation offspring were mated to produce a second generation (F2) without any further dietary change. The same procedure produced an F3 generation. Blood pressure in all generations was determined at 4, 6 and 8 weeks of age and nephron number was determined at 10 weeks of age. F1 generation MLP-exposed offspring exhibited raised (P < 0.001) systolic blood pressure (male 143 (sem 4) mmHg; female 141 (sem 4) mmHg) compared with CON animals (male 132 (sem 3) mmHg; female 134 (sem 4) mmHg). Raised blood pressure and reduced nephron number was also noted in the F2 generation (P < 0.001) and this intergenerational transmission occurred via both the maternal and paternal lines, as all three possible offspring crosses (MLP x CON, CON x MLP and MLP x MLP) were hypertensive (132 (sem 3) mmHg) compared with CON animals (CON x CON; 123 (sem 2) mmHg). No effect was noted in the F3 generation. It is concluded that fetal protein restriction may play a critical role in determining blood pressure and overall disease risk in a subsequent generation. |
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Authors:
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Matthew Harrison; Simon C Langley-Evans |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-09 |
Journal Detail:
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Title: The British journal of nutrition Volume: 101 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-03 Completed Date: 2009-06-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1020-30 Citation Subset: IM |
Affiliation:
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University of Nottingham, School of Biosciences, Sutton Bonington, Loughborough LE12 5RD, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Body Composition Breeding Cell Count Cholesterol / blood Diet, Protein-Restricted* Dietary Fats / administration & dosage Female Hypertension / embryology*, pathology Kidney / embryology*, pathology Male Maternal Nutritional Physiological Phenomena* Models, Animal Nephrons / pathology Pregnancy Prenatal Nutritional Physiological Phenomena* Rats Rats, Wistar Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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PG/06/119/21522//British Heart Foundation; //British Heart Foundation |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Triglycerides; 57-88-5/Cholesterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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