| Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams. | |
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MedLine Citation:
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PMID: 18609307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gestational cocaine treatment results in significantly increased maternal aggression towards an intruder by postpartum day six, while acute postpartum treatment dose dependently decreases maternal aggressive (MA) behavior. Both increased and decreased aggression in the cocaine-treated dams are correlated with either decreased or increased levels of oxytocin in the amygdala, respectively. The current study was an effort to determine whether the effect of gestational cocaine on maternal aggression is transient or would continue into the postpartum period; whether an intermittent cocaine treatment regimen, which incorporates gestational and postpartum intermittent cocaine treatment, would differ from chronic daily gestational treatment; and finally, whether next generation female offspring of cocaine-treated or control dams would have altered MA behavior and oxytocin system changes attributable to either prenatal drug exposure, rearing condition or both. We now report no increase in maternal aggression following chronic gestational treatment and significantly lower levels of aggression in intermittently treated dams on postpartum day eight, with no significant effects in either group on postpartum day 12. Young adult female offspring of the cocaine-treated and control dams, who reared their own natural litters and were tested on postpartum day eight for maternal aggression, had higher levels of maternal aggression towards an intruder attributable to both prenatal cocaine exposure and rearing condition. Higher aggression in cocaine-reared next generation dams was associated with lower levels of oxytocin in the amygdala. Intergenerational effects of cocaine were apparent with respect to aggression and oxytocin system changes. |
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Authors:
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M S McMurray; P W Joyner; C W Middleton; T M Jarrett; D L Elliott; M A Black; V E Hofler; C H Walker; J M Johns |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Stress (Amsterdam, Netherlands) Volume: 11 ISSN: 1607-8888 ISO Abbreviation: Stress Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-22 Completed Date: 2008-10-31 Revised Date: 2012-03-19 |
Medline Journal Info:
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Nlm Unique ID: 9617529 Medline TA: Stress Country: England |
Other Details:
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Languages: eng Pagination: 398-410 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. mcmurray@med.unc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aggression
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drug effects* Animals Brain Chemistry Cocaine / administration & dosage, pharmacology* Female Male Maternal Behavior / drug effects* Oxytocin / physiology Postpartum Period* Pregnancy Prenatal Exposure Delayed Effects* Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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DA13283/DA/NIDA NIH HHS; DA13362/DA/NIDA NIH HHS; R01 DA013283-05/DA/NIDA NIH HHS; R01 DA013362-04/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 50-56-6/Oxytocin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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