| Interfractional Reproducibility in Pancreatic Position Based on Four-Dimensional Computed Tomography. | |
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MedLine Citation:
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PMID: 21493016 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To assess the interfractional positional variation of the pancreas using four-dimensional computed tomography (4D-CT) and to determine the suitable phase of respiration for dose delivery methods to account for pancreatic tumor motion. METHODS AND MATERIALS: Fifteen patients with pancreatic cancer were enrolled in this study. For each patient, 4D-CT scans were performed at CT simulation and three times during the course of treatment. Regions of interest were set to the intrapancreatic bile ducts as a surrogate for pancreatic position. The centroids of the regions of interest were calculated at end-inhalation and end-exhalation of the respiration phase. The ranges of respiratory motion and interfractional positional variation were evaluated in the left-right (LR), anterior-posterior (AP), and superior-inferior (SI) directions. RESULTS: The medians of respiratory motion were 1.1 mm (range, 0.0-9.8 mm), 1.5 mm (range, 0.0-7.0 mm), and 5.0 mm (range, 0.0-12.5 mm) in the LR, AP, and SI directions, respectively. The means ± SDs of the interfractional positional variation at end-inhalation were 0.9 ± 5.1 mm (range, -9.2 to 15.6 mm), -1.9 ± 3.9 mm (range, -12.8 to 6.4 mm), and -1.3 ± 6.9 mm (range, -15.0 to 13.7 mm) and those at end-exhalation were 0.0 ± 3.1 mm (range, -7.0 to 5.3 mm), -1.2 ± 3.9 mm (range, -11.2 to 6.7 mm), and 0.1 ± 3.2 mm (range, -9.9 to 5.1 mm) in the LR, AP, and SI directions, respectively. The SDs of the interfractional positional variation in the LR and SI directions were significantly larger at end-inhalation than at end-exhalation (LR, p < 0.001; SI, p < 0.001). CONCLUSIONS: The ranges of respiratory motion during the course of treatment and the interfractional positional variation were not negligible. The interfractional positional reproducibility was higher at end-exhalation than at end-inhalation under free breathing. |
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Authors:
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Takehiro Shiinoki; Keiko Shibuya; Mitsuhiro Nakamura; Akira Nakamura; Yukinori Matsuo; Manabu Nakata; Akira Sawada; Takashi Mizowaki; Akio Itoh; Masahiro Hiraoka |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-12 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: - ISSN: 1879-355X ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Nuclear Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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