| Interferons and microRNAs. | |
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MedLine Citation:
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PMID: 20939680 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Plants rely heavily on an adaptive RNA degradation system mediated by an RNA interference mechanism to combat viral infection, whereas mammals fight infection with specific antibodies and lymphocytes that are adapted to specific viral antigens, and also employ nonadaptive defenses, such as production of interferons (IFNs) that block viral replication and stimulate the host immune response. Therefore, the IFN system represents an integral part of the mammalian antiviral innate immunity, and it is not surprising to find that cellular, IFN-regulated microRNAs contribute to this antiviral defense. In contrast, virus-encoded microRNAs target host cell factors that are either required for the induction of IFNs after pathogen recognition, or are involved in the cellular responses to these pleiotropic cytokines. |
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Authors:
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Michael David |
Publication Detail:
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Type: Journal Article Date: 2010-10-12 |
Journal Detail:
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Title: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research Volume: 30 ISSN: 1557-7465 ISO Abbreviation: J. Interferon Cytokine Res. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9507088 Medline TA: J Interferon Cytokine Res Country: United States |
Other Details:
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Languages: eng Pagination: 825-8 Citation Subset: IM |
Affiliation:
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Division of Biological Sciences, University of California , San Diego, La Jolla, California 92093-0322, USA. midavid@ucsd.edu |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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