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Interferon treatment for patients with chronic hepatitis C complicated with chronic renal failure receiving hemodialysis.
MedLine Citation:
PMID:  23302054     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND/AIMS: The Japan Society for Dialysis Therapy established "Guidelines for the Treatment of Hepatitis C Virus Infection in Dialysis Patients". We evaluated the status of HCV infection and the treatment of hemodialysis patients in Gunma prefecture. METHODS: Questionnaires concerning the infection rate, recognition of the guidelines, and treatment status were sent to all 64 hospitals/clinics which had hemodialysis systems in Gunma prefecture. The HCV-infected hemodialysis patients who received pegylated-interferon (peg-IFN) were analyzed at Gunma University Hospital. RESULTS: The positive rate for HCV antibody was 256/2582 hemodialysis patients (9.9%). The positive rate varied between institutions (range; 0-40.0%, median; 9.0%). All institutes recognized the establishment of the guidelines. Conventional or peg-IFN treatment was being given at 37.5% of the institutions. The other 62.5% institutions answered that they intended to provide the treatment in the future if collaboration with a hepatologist could be arranged. The most common answers regarding the indication for IFN treatment were as follows; few complications, under 60 years of age, more than 10 years of survival expected on hemodialysis. Eighteen patients received peg-IFN treatment. The sustained virological response (SVR) rate of all patients was 33.3%; 0% in Ib/high viral titer, 50% in genotype 2, 100% in genotype 2/low viral titer. The SVR rate was worse in the patients with 1b/high viral load and diabetic nephropathy (P<0.05). CONCLUSIONS: Recognition of the publication of the guidelines was high. However, the number of patients treated with peg-IFN was still low. Further enlightenment and cooperation between hemodialysis teams and hepatologists is therefore needed.
Authors:
Akira Kojima; Satoru Kakizaki; Ken-Ichi Hosonuma; Yuichi Yamazaki; Norio Horiguchi; Ken Sato; Tokuyuki Kitahara; Masatomo Mori
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Affiliation:
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan.
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