Document Detail

Interferon treatment inhibits glycosylation of a viral protein.
MedLine Citation:
PMID:  6159539     Owner:  NLM     Status:  MEDLINE    
Earlier, we reported a 30-200-fold reduction in the yield of infectious vesicular stomatitis virus (VSV) released from L cells treated with 10-30 reference units ml-1 of interferon (IFN); however, in these cultures virus particle production, as measured by VSV particle-associated viral RNA, virus nucleocapsid protein and viral transcriptase, was inhibited less than 10-fold. There was biochemical and morphological evidence of a significant reduction in glycoprotein (G) and membrane protein (M) of VSV particles released from IFN-treated cells. We compare here the effects of tunicamycin (TM) and IFN in L cells. Treatment with TM or IFN reduced the production of infectious VSV particles, decreased the amount of G and M proteins in VSV released from treated cells, and inhibited an early step in the formation of asparagine-linked oligosaccharide chains, the incorporation by membrane preparations from treated cells of N-acetylglucosamine into glycolipids with the properties of dolichol derivatives.
R K Maheshwari; D K Banerjee; C J Waechter; K Olden; R M Friedman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature     Volume:  287     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1981-01-16     Completed Date:  1981-01-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  454-6     Citation Subset:  IM    
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MeSH Terms
Dolichol Phosphates / metabolism
Glucosamine / analogs & derivatives*
Glycoproteins / biosynthesis*
Interferons / pharmacology*
Tunicamycin / pharmacology*
Uridine Diphosphate N-Acetylglucosamine / metabolism
Vesicular stomatitis Indiana virus / drug effects*
Viral Proteins / biosynthesis*
Virus Replication / drug effects
Reg. No./Substance:
0/Dolichol Phosphates; 0/Glycoproteins; 0/Viral Proteins; 11089-65-9/Tunicamycin; 3416-24-8/Glucosamine; 528-04-1/Uridine Diphosphate N-Acetylglucosamine; 9008-11-1/Interferons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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