| Interferon for the therapy of condyloma acuminatum. | |
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MedLine Citation:
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PMID: 3898846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphoblastoid interferon, Wellferon, was used to treat patients with resistant and persistent condyloma acuminatum at initial doses of 5, 3, and 1 million unit/square meter (Mu/M2). The objectives of this study were to evaluate the efficacy and toxicity of, and tolerance to, intramuscular and intralesional interferon. Seventeen patients were treated with 5 Mu/M2, 14 patients with 1 Mu/M2, and 37 patients with 3 Mu/M2; daily administration was followed by three-times-a-week dosing. The complete response rate in patients receiving initial dose of interferon of 5 Mu/M2 was 69%, that for doses of 1 Mu/M2 was 43%, and that for doses of 3 Mu/M2 was 57%. All patients given interferon developed initial elevations of temperature of limited duration, whereas all patients given the 5 Mu/M2 dose had to have the amount reduced because of biologic side effects. However, only five of 37 (14%) of the patients given 3 Mu/M2 required a reduction in the dosage, and no patient given 1 Mu/M2 needed to have the dosage reduced. These studies suggest that interferon is efficacious in the treatment of resistant and persistent condyloma acuminatum, and that the biologic side effects were dose-related, well tolerated, and not life-threatening. |
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Authors:
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S A Gall; C E Hughes; K Trofatter |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 153 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1985-10-21 Completed Date: 1985-10-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 157-63 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine Transaminase / blood Aspartate Aminotransferases / blood Blood Cell Count Clinical Trials as Topic Condylomata Acuminata / enzymology, therapy* Drug Administration Schedule Fatigue / chemically induced Female Genital Neoplasms, Female / enzymology, therapy* Genital Neoplasms, Male / enzymology, therapy* Humans Interferon Type I / adverse effects, therapeutic use* Male Nausea / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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