| Interferon regulatory factor 5 polymorphisms in sarcoidosis. | |
| | |
MedLine Citation:
|
PMID: 23288367 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: Interferon regulatory factor 5 (IRF5) gene polymorphisms are associated with susceptibility to autoimmune diseases. The aim of this study is to determine the roles of IRF5 single-nucleotide polymorphisms (SNPs) in sarcoidosis. METHODS: A total of 175 Japanese patients with biopsy-proven sarcoidosis and 150 sex-matched controls were genotyped for four IRF5 SNPs: rs729302A/C, rs2004640G/T, rs10954213A/G, and rs2280714G/A. The associations of these SNPs with susceptibility to sarcoidosis were examined. RESULTS: Carriage of rs10954213A and rs2280714A conferred significant risks for sarcoidosis [carriage of rs10954213A: odds ratio (OR) = 1.96, 95 % confidence interval (CI) = 1.15-3.33, P = 0.01, corrected P = 0.04; carriage of rs2280714A: OR = 1.97, 95 % CI = 1.22-3.16, P = 0.005, corrected P = 0.02]. The haplotype carrying rs10954213A and rs2280714A (haplotype 2) was significantly associated with susceptibility to sarcoidosis (OR = 2.00, 95 % CI = 1.24-3.24, P = 0.004, corrected P = 0.01). rs729302 and rs2004640 were not associated with susceptibility to sarcoidosis, whereas carriage of rs2004640G was protective against pulmonary hypertension (OR = 0.017, 95 % CI = 0.002-0.15, P < 0.001, corrected P < 0.001). CONCLUSION: A haplotype carrying two functional SNPs of IRF5, rs10954213A and rs2280714A, was associated with the risk of sarcoidosis in the Japanese population. |
| | |
Authors:
|
Kiminobu Tanizawa; Tomohiro Handa; Sonoko Nagai; Hiroe Sato; Ryo Yamada; Isao Ito; Takeshi Kubo; Yutaka Ito; Kizuku Watanabe; Kensaku Aihara; Kohei Ikezoe; Michiaki Mishima; Takateru Izumi |
Related Documents
:
|
8556817 - A rare g6490-->a substitution at the last nucleotide of exon 10 of the glucocerebrosida... 9153297 - Identification and expression of acid beta-glucosidase mutations causing severe type 1 ... 23043317 - Rhd and rhce variant and zygosity genotyping via multiplex ligation-dependent probe amp... 23050857 - Late-onset myopathy of the posterior calf muscles mimicking miyoshi myopathy unrelated ... 15119327 - A brief history of the political work of genetics. 12032747 - A meta-analytic investigation of linkage and association of common leptin receptor (lep... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-4 |
Journal Detail:
|
Title: Modern rheumatology / the Japan Rheumatism Association Volume: - ISSN: 1439-7609 ISO Abbreviation: Mod Rheumatol Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100959226 Medline TA: Mod Rheumatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan, tanizawa@kuhp.kyoto-u.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Conserved host-pathogen PPIs.
Next Document: Pediatric intracranial aneurysms: current national trends in patient management and treatment.