Document Detail

Interferon production in mouse spleen cells and mouse fibroblasts (L cells) stimulated by various strains of Newcastle disease virus.
MedLine Citation:
PMID:  6183397     Owner:  NLM     Status:  MEDLINE    
Interferon production in mouse spleen cells and mouse fibroblasts (L cells) stimulated by three strains of Newcastle disease virus (NDV), Italian, La Sota and Ulster, was investigated. Strain Italian was fully infectious and highly virulent; strain Ulster exhibited very low infectivity and very low virulence; strain La Sota was between these extremes. All of these strains of MDBK cell-grown NDV could induce interferon in mouse spleen cells, and it was concluded that proteolytic cleavage of F0 protein of NDV and, consequently, virus penetration are not necessary for interferon induction in these cells. On the other hand, NDV with uncleaved F0, which was characterized by an apparent lack of haemolytic and cell fusion activity and infectivity for tissue culture cells, had no interferon-inducing ability in L cells. The cleavage of F0 protein was paralleled by an appearance of interferon-inducing activity in L cells.
Y Ito; Y Nagai; K Maeno
Related Documents :
12573577 - Cell-surface-expressed hiv-1 envelope induces the death of cd4 t cells during gp41-medi...
19564597 - Syncytin-a knockout mice demonstrate the critical role in placentation of a fusogenic, ...
2398347 - Cellular events during sexual development from amoeba to plasmodium in the slime mould ...
5274477 - Introduction of a heterologous nucleus into enucleated cytoplasms of cultured mouse l-c...
21302307 - Human salivary gland acinar cells spontaneously form three-dimensional structures and c...
8508947 - Different propensity for spontaneous differentiation of cell clones isolated from the h...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of general virology     Volume:  62 (Pt 2)     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  349-52     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cells, Cultured
Guinea Pigs
Interferons / biosynthesis*
Newcastle disease virus / immunology*
Spleen / immunology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biochemical analysis and electron microscopic study on intracellular virions in NIH/3T3 mouse cells ...
Next Document:  Co-occurrence of HBsAg and anti-HBs: two consecutive infections or a sign of advanced chronic liver ...