Document Detail

Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm.
MedLine Citation:
PMID:  2446135     Owner:  NLM     Status:  MEDLINE    
In most species the length of a pregnancy exceeds that of the luteal phase of the ovarian cycle. The conceptus within the uterus, therefore, is believed to produce a substance or substances which directly or indirectly prolong the lifespan of the corpus luteum and prevent a return to ovarian cyclicity. This phenomenon is known as maternal recognition of pregnancy. The active substance implicated in signalling maternal recognition of pregnancy in the sheep is an embryonic secretory protein, known as ovine trophoblast protein-1 (oTP-1) (refs 2-4), which is targeted in a paracrine manner to the uterine epithelium of the mother. We report here the primary amino-acid sequence of oTP-1 as inferred from a cloned complementary DNA and demonstrate that the protein is most probably an interferon-alpha.
K Imakawa; R V Anthony; M Kazemi; K R Marotti; H G Polites; R M Roberts
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  330     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:    1987 Nov 26-Dec 2
Date Detail:
Created Date:  1987-12-23     Completed Date:  1987-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  377-9     Citation Subset:  IM    
Department of Animal Sciences, University of Missouri, Columbia 65211.
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MeSH Terms
Amino Acid Sequence
Base Sequence
DNA / analysis
Ectoderm / secretion*
Interferon Type I*
Interferons / genetics*
Molecular Sequence Data
Pregnancy Proteins / genetics*,  secretion
Reg. No./Substance:
0/Interferon Type I; 0/Pregnancy Proteins; 0/trophoblastin; 9007-49-2/DNA; 9008-11-1/Interferons

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