| [Interferon induction increased through chemical modification of a synthetic polyribonucleotide]. | |
| | |
MedLine Citation:
|
PMID: 5801596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The alternating copolymer riboadenylic-ribouridylic acid gained asignificant increase in ability to stimulate interferon production (2-to 20-fold) and cellular resistance (100-to 10,000-fold) both in vitro and in vivo upon substitution of phosphate by thiophosphate groups. The resulting nucleotide analog was also 10 to 100 times less sensitive to degradation by pancreatic ribonuclease, as determined byresidual antiviral activity. |
| | |
Authors:
|
E De Clercq; E Eckstein; T C Merigan |
Related Documents
:
|
11562956 - Synthesis and study of the fluorescein conjugate of the nucleotide dptp. 22687776 - Non-methylene-interrupted fatty acids with Δ5 unsaturation in sargassum species. 1426996 - Anthranilic acid release in adenosine-inhibited cultures of saccharomyces cerevisiae an... 12398346 - Differentiation between unlabeled and very-low-level fully 15n,13c-labeled nucleotides ... 19366 - Explanation of the observation of pancreatic ribonuclease activity at ph 4.5. 2536716 - Changes in the concentration and fatty acid composition of phosphoinositides induced by... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Science (New York, N.Y.) Volume: 165 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1969 Sep |
Date Detail:
|
Created Date: 1969-09-30 Completed Date: 1969-09-30 Revised Date: 2011-12-07 |
Medline Journal Info:
|
Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1137-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antiviral Agents / pharmacology* Culture Techniques Fibroblasts / drug effects Humans Interferons / biosynthesis* Phosphates Polynucleotides / chemical synthesis*, pharmacology Rabbits Ribonucleases / metabolism Skin Sulfur |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 0/Phosphates; 0/Polynucleotides; 7704-34-9/Sulfur; 9008-11-1/Interferons; EC 3.1.-/Ribonucleases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tumor induction in developing frog kidneys by a zonal centrifuge purified fraction of the frog herpe...
Next Document: Studying neural organization in Aplysia with the scanning electron microscope.