Document Detail

Interferon induction in piglets with polyinosinic:polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose.
MedLine Citation:
PMID:  2453906     Owner:  NLM     Status:  MEDLINE    
When newborn piglets were inoculated intravenously with 1.0, 0.5 or 0.25 mg kg-1 of polyinosinic:polycytidylic acid (poly I:C) complexed with poly-L-lysine and carboxymethylcellulose (poly ICLC), the highest serum interferon levels and the lowest white blood cell counts were found in response to a dose of 0.5 mg kg-1. Similar responses were observed in weaned piglets inoculated with 0.25 mg kg-1 of poly ICLC. Poly ICLC was a more effective interferon inducer than poly I:C, particularly in newborn piglets.
K G Loewen; J B Derbyshire
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research in veterinary science     Volume:  44     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-06-24     Completed Date:  1988-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  132-3     Citation Subset:  IM    
Department of Veterinary Microbiology and Immunology, University of Guelph, Canada.
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MeSH Terms
Animals, Newborn / blood*
Carboxymethylcellulose / pharmacology*
Interferon Inducers / pharmacology*
Interferons / blood*
Leukocyte Count / veterinary
Methylcellulose / analogs & derivatives*
Poly I-C / pharmacology*
Polylysine / pharmacology*
Swine / blood*
Reg. No./Substance:
0/Interferon Inducers; 24939-03-5/Poly I-C; 25104-18-1/Polylysine; 59789-29-6/poly ICLC; 9004-32-4/Carboxymethylcellulose; 9004-67-5/Methylcellulose; 9008-11-1/Interferons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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