Document Detail


Interferon induces cell fusion and the formation of multinuclear cells in a culture of Ehrlich ascites tumor cells.
MedLine Citation:
PMID:  3372601     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The increase in number of Ehrlich ascites tumor (EAT) cells was diminished significantly when the cell culture was treated with 1,000 IU/ml of recombinant mouse alpha or beta interferon (IFN). Microscopical observation revealed that almost all the cells showed bi- or multinuclear morphology 3 to 5 days after IFN treatment. Furthermore, a videorecording showed that each multinuclear cell arose by fusion after mitotic division of one parental cell.
Authors:
S Tominaga
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  135     ISSN:  0021-9541     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-07-05     Completed Date:  1988-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  350-4     Citation Subset:  IM    
Affiliation:
Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Ehrlich Tumor / pathology*
Cell Division / drug effects
Cell Fusion / drug effects
Cell Nucleus / drug effects,  ultrastructure
Interferon Type I / physiology*
Kinetics
Mice
Recombinant Proteins / pharmacology*
Chemical
Reg. No./Substance:
0/Interferon Type I; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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