| Interferon induces cell fusion and the formation of multinuclear cells in a culture of Ehrlich ascites tumor cells. | |
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MedLine Citation:
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PMID: 3372601 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The increase in number of Ehrlich ascites tumor (EAT) cells was diminished significantly when the cell culture was treated with 1,000 IU/ml of recombinant mouse alpha or beta interferon (IFN). Microscopical observation revealed that almost all the cells showed bi- or multinuclear morphology 3 to 5 days after IFN treatment. Furthermore, a videorecording showed that each multinuclear cell arose by fusion after mitotic division of one parental cell. |
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Authors:
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S Tominaga |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cellular physiology Volume: 135 ISSN: 0021-9541 ISO Abbreviation: J. Cell. Physiol. Publication Date: 1988 May |
Date Detail:
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Created Date: 1988-07-05 Completed Date: 1988-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0050222 Medline TA: J Cell Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 350-4 Citation Subset: IM |
Affiliation:
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Okinaka Memorial Institute for Medical Research, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Ehrlich Tumor / pathology* Cell Division / drug effects Cell Fusion / drug effects Cell Nucleus / drug effects, ultrastructure Interferon Type I / physiology* Kinetics Mice Recombinant Proteins / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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