Document Detail

Interferon γ in patients with HIV/AIDS and suspicion or latent tuberculosis infection.
MedLine Citation:
PMID:  23339916     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To assess the usefulness of IGRA test (QuantiFERON®-Cell mediated immune) compared with the tuberculin skin test.
METHODS: A cross-sectional study was carried out in Mexico, 25 infected patients with HIV-AIDS and the suspicion or with latent tuberculous infection (LTBI) who were >18 years of age and without treatment for tuberculosis (TB), were enrolled in the study.
RESULTS: Median cluster of differentiation (CD4) count was 364 cells/μ L and median HIV viral load was 50 copies/mL. Overall, 20 patients (80%) had at least one positive diagnostic test for LTBI: four (16%) had a positive tuberculin skin test and 19 (76%), a positive QuantiFERON®-tuberculosis.
CONCLUSIONS: No agreement is found between the two diagnostic tests: k = -0.004, 95% confidence interval (-0.2219, 0.2210). Additional longitudinal studies among HIV-infected populations with high prevalence of TB are needed to further assess the usefulness of IGRAs in this patient population.
Guadalupe García-Elorriaga; Mayté Martínez-Velázquez; Verónica Gaona-Flores; Guillermo Del Rey-Pineda; César González-Bonilla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of tropical medicine     Volume:  6     ISSN:  1995-7645     ISO Abbreviation:  Asian Pac J Trop Med     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101533720     Medline TA:  Asian Pac J Trop Med     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Hainan Medical College. Published by Elsevier B.V. All rights reserved.
Unidad de Investigación en Inmunología e Infectología, Centro Médico Nacional La Raza (CMNR), Instituto Mexicano del Seguro Social (IMSS) Mexico City, Mexico. Electronic address:
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