Document Detail


Interferon-alpha treatment of Behçet's disease.
MedLine Citation:
PMID:  9779847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if interferon-alpha (IFN-alpha) is effective in Behçet's disease (BD). METHODS: Ten patients having active BD were entered into a 6 month open label trial of IFN-alpha therapy given by self-administered dose of 3 million units subcutaneously daily. Provision was made for downward or upward dosing depending on predetermined responses. Four study centers followed the same protocol. Patients having ocular or neurologic inflammation at onset of the study were excluded. RESULTS: Seven patients completed the trial, while 3 were removed at 3 and 4 months for side effects or lack of efficacy. There was a substantial reduction in the number of oral and genital ulcers, cutaneous lesions, and articular signs and symptoms by the end of the study. Pain scores, global assessments, and prednisone dose also declined. The IFN-alpha dose at end of study averaged 1.5 million units. Significant side effects, besides the anticipated flu-like syndrome experienced by all the patients, included single instances of seizure, psychosis, psoriasis, and hyperthyroidism. CONCLUSION: The results suggest that IFN-alpha is effective therapy for some manifestations of Behçet's disease.
Authors:
J D O'Duffy; K Calamia; S Cohen; J J Goronzy; D Herman; J Jorizzo; C Weyand; E Matteson
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  25     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-04     Completed Date:  1999-01-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1938-44     Citation Subset:  IM    
Affiliation:
Mayo Clinic, Rochester, Minnesota 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Behcet Syndrome / drug therapy*
Female
Genital Diseases, Female / drug therapy
Genital Diseases, Male / drug therapy
Humans
Interferon-alpha / therapeutic use*
Joint Diseases / drug therapy
Male
Middle Aged
Oral Ulcer / drug therapy
Skin Ulcer / drug therapy
Treatment Outcome
Ulcer / drug therapy
Chemical
Reg. No./Substance:
0/Interferon-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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