Document Detail


Interferon induced with helicase C domain 1 (IFIH1) and virus-induced autoimmunity: a review.
MedLine Citation:
PMID:  20121398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to genetic factors, environmental triggers, including viruses and other pathogens, are thought to play a major role in the development of autoimmune disease. Recent findings have shown that viral-induced autoimmunity is likely to be genetically determined. In large-scale genetic analyses, an association of interferon induced with helicase C domain 1 (IFIH1) gene variants encoding a viral RNA-sensing helicase with susceptibility to several autoimmune diseases was found. To date, the precise role of IFIH1 in pathogenic mechanisms of viral-induced autoimmunity has yet to be fully elucidated. However, recent reports suggest that IFIH1 may play a role in the etiology of type 1 diabetes. Rare IFIH1 alleles have been shown to be protective against diabetes, and their carriage correlates with lower production of this helicase and its functional disruption. In contrast, upregulation of IFIH1 expression by viruses is associated with more severe disease, and could exacerbate the autoimmune process in susceptible individuals.
Authors:
Dimitry A Chistiakov
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Viral immunology     Volume:  23     ISSN:  1557-8976     ISO Abbreviation:  Viral Immunol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801552     Medline TA:  Viral Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-15     Citation Subset:  IM    
Affiliation:
Department of Molecular Diagnostics, National Research Center GosNIIgenetika, Moscow, Russia.
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MeSH Terms
Descriptor/Qualifier:
Autoimmune Diseases / epidemiology*
DEAD-box RNA Helicases / genetics*,  immunology*
Disease Susceptibility
Humans
Immunity, Innate
Interferons
Polymorphism, Genetic*
Virus Diseases / complications*,  immunology*
Chemical
Reg. No./Substance:
9008-11-1/Interferons; EC 3.6.1.-/DEAD-box RNA Helicases; EC 3.6.1.-/IFIH1 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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