Document Detail

Interferon Alfa-associated Anterior Ischemic Optic Neuropathy.
MedLine Citation:
PMID:  20630599     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: To report a possible association between interferon alfa therapy and anterior ischemic optic neuropathy (AION).
DESIGN: Database study and review of the literature.
PARTICIPANTS: Thirty-six case reports from spontaneous reporting systems and the literature.
METHODS: Case reports from a review of the literature were combined with spontaneous reports from the National Registry of Drug-Induced Ocular Side Effects, the World Health Organization, and the Food and Drug Administration looking for reports on interferon therapy associated with optic neuropathy.
MAIN OUTCOME MEASURES: Data from the spontaneous reports include the type of interferon, age, gender, adverse drug reaction (ADR), dosage, duration of therapy until onset of ADR, concomitant drugs, systemic disease, and dechallenge and rechallenge data.
RESULTS: Thirty-six case reports of AION are described in association with interferon alfa therapy. The average age of subjects was 54.5 years; 26 were male and 10 were female. The median duration of therapy to onset of AION was 4.5 months, with 50% of subjects having some form of permanent vision loss. Anterior ischemic optic neuropathy was bilateral in 67% of subjects. There are 3 positive rechallenge case reports.
CONCLUSIONS: Interferon alfa's association with AION can be classified as "possible" using the World Health Organization classification system. If optic neuropathy is suspected, rapid cessation of interferon therapy may portend a better prognosis because multiple case reports indicate visual defects may be permanent if this possible ADR remains unrecognized.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
F W Fraunfelder; F T Fraunfelder
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Publication Detail:
Type:  Journal Article     Date:  2010-07-14
Journal Detail:
Title:  Ophthalmology     Volume:  118     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  408-411.e2     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
Department of Ophthalmology (Casey Eye Institute), Oregon Health & Science University, Portland, Oregon.
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