| Interference of retinoic acid binding to its binding protein by omega-6 fatty acids. | |
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MedLine Citation:
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PMID: 2820396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cellular retinoic acid-binding protein (CRABP) is the putative mediator of the biological effects of retinoic acid in the control of epithelial differentiation and tumorigenesis. Omega-6 fatty acids such as linoleic acid and arachidonic acid, precursors of prostaglandin synthesis, caused inhibition of retinoic acid binding to CRABP. These fatty acids, however, possessed lower affinity than retinoic acid for the binding protein. Omega-3 fatty acids, such as eicosapentaenoic acid and docosohexaenoic acid, did not cause such inhibition in the binding of retinoic acid. Whereas retinoic acid was a potent modulator of differentiation of F9 embryonal carcinoma cells, neither omega-3 nor omega-6 fatty acids showed any significant differentiation potential. Competition by omega-6 fatty acids with retinoic acid for CRABP may neutralize the binding protein-mediated biological functions of retinoic acid, and could thereby enhance tumor production. |
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Authors:
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B P Sani; R D Allen; C M Moorer; B W McGee |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 147 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1987 Aug |
Date Detail:
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Created Date: 1987-10-08 Completed Date: 1987-10-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 25-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid Arachidonic Acids / metabolism* Binding, Competitive Carrier Proteins / metabolism* Chick Embryo Fatty Acids, Unsaturated / metabolism* Linoleic Acid Linoleic Acids / metabolism* Oleic Acid Oleic Acids / metabolism Plasminogen Activators / metabolism Receptors, Retinoic Acid Structure-Activity Relationship Tretinoin / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA 40756/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Carrier Proteins; 0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 0/Oleic Acids; 0/Receptors, Retinoic Acid; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid; 302-79-4/Tretinoin; 506-32-1/Arachidonic Acid; EC 3.4.21.-/Plasminogen Activators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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