Document Detail

Interference of pathway specific transcription factors.
MedLine Citation:
PMID:  1536876     Owner:  NLM     Status:  MEDLINE    
A mechanism for reversibility of cellular decisions, e.g., proliferation or differentiation, is mediated by direct interference of pathway-specific transcription factors. Due to the relative activity of the transcription factors, genetic programs are reversibly switched on and off. In the case of the transcription factors AP-1 and the family of steroid hormone receptors (including retinoic acid receptor, thyroid hormone and vitamin D receptors) two different mechanisms account for negative interference. In one case overlapping DNA binding sites are suggestive of mutually exclusive binding of transcription factors to account for repression. In the other case, a DNA bound transcription factor is attacked by another one via protein-protein interaction, without the need of the latter factor binding to DNA. Although it is not excluded, that also in the case of overlapping DNA binding elements protein-protein interaction might in fact be responsible for repression instead of substitution, the two situations can be clearly distinguished by specific mutants in the glucocorticoid receptor and in Jun and Fos. For the interaction mechanism, we favor the interpretation that the binding of one transcription factor to another one interferes with transactivation directly without influence on DNA binding. The fact that at least two different mechanisms are established to guarantee effective interference, demonstrates how important this type of transcription factor crosstalk is.
H Ponta; A C Cato; P Herrlich
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1129     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-01     Completed Date:  1992-04-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  255-61     Citation Subset:  IM    
Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Germany.
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MeSH Terms
Amino Acid Sequence
Amino Acids / genetics
DNA-Binding Proteins / metabolism
Molecular Sequence Data
Receptors, Glucocorticoid / genetics,  metabolism*
Transcription Factors / metabolism*
Reg. No./Substance:
0/Amino Acids; 0/DNA-Binding Proteins; 0/Receptors, Glucocorticoid; 0/Transcription Factors

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