Document Detail

Interference of oral phenytoin absorption by enteral tube feedings.
MedLine Citation:
PMID:  3138965     Owner:  NLM     Status:  MEDLINE    
The medical records of 11 brain-injured patients, simultaneously on enteral tube feeding and phenytoin, were retrospectively reviewed for evidence of interference of phenytoin absorption. One case demonstrated no interference. Three cases suggested depression of serum phenytoin levels by enteral formula, but the contribution of other factors could not be ruled out. Seven cases did appear to reflect a direct alteration of phenytoin levels by enteral formula. To achieve adequate serum phenytoin levels, patients may need (1) large oral phenytoin doses above that recommended while on continuous enteral feedings, (2) administration of oral phenytoin between intermittent enteral feedings, or (3) a choice of alternative anticonvulsants which have been shown to be unaffected by enteral formula.
R C Sneed; W T Morgan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  69     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-17     Completed Date:  1988-10-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  682-4     Citation Subset:  AIM; IM    
Department of Rehabilitation Medicine, University of Alabama, Birmingham 35233.
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MeSH Terms
Brain Injuries / complications,  drug therapy,  metabolism*
Child, Preschool
Enteral Nutrition*
Phenytoin / metabolism*,  therapeutic use
Seizures / prevention & control*
Reg. No./Substance:

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