Document Detail

Interference of lung distension with the cardiovascular response to chemoreceptor stimulation in anaesthetized rats.
MedLine Citation:
PMID:  1723327     Owner:  NLM     Status:  MEDLINE    
Experiments were performed to examine the role of the stimulation of pulmonary stretch receptors in cardiovascular response to peripheral chemoreceptor stimulation in spontaneously breathing anaesthetized rats. The effects of continuous positive tracheal pressure (0.1 to 0.4 kPa) were examined in normal rats and in rats pretreated with almitrine bismesylate, a potent stimulator of the arterial chemoreceptors. In the untreated group, an increase of a maximum 4 +/- 0.7 beats.min-1 in heart rate was found during testing at pressure of 0.2 and 0.3 kPa when interference with augmented breath was avoided. These pressures at the tracheal level had no effect on systemic blood pressure, so that baroreflex influences can be discounted. During strong almitrine-induced chemostimulation, a prolonged bradycardia developed with the long-lasting hyperventilation. The same continuous positive pressures were unable to overcome the chemoreflex bradycardia. No changes in heart rate were observed under these conditions, whatever the potentiation of the mecanoreceptors for distension in the presence of alveolar hypocapnia. It was concluded that the stretching of lung mecanoreceptors on the cardiac control is of little importance in anaesthetized rats and that bradycardia generally dominates during strong stimulation of the chemoreceptors even when lung distension is artificially increased.
D Lagneaux
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives internationales de physiologie, de biochimie et de biophysique     Volume:  99     ISSN:  0778-3124     ISO Abbreviation:  Arch Int Physiol Biochim Biophys     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-03-12     Completed Date:  1992-03-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9111069     Medline TA:  Arch Int Physiol Biochim Biophys     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  349-54     Citation Subset:  IM; S    
Institut Léon Fredericq, Physiologie, Université de Liège, Belgique.
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MeSH Terms
Almitrine / pharmacology
Cardiovascular Physiological Phenomena*
Chemoreceptor Cells / drug effects,  physiology*
Heart Rate / drug effects
Lung / physiology*
Mechanoreceptors / physiology*
Rats, Inbred Strains
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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