| Interference of lung distension with the cardiovascular response to chemoreceptor stimulation in anaesthetized rats. | |
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MedLine Citation:
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PMID: 1723327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experiments were performed to examine the role of the stimulation of pulmonary stretch receptors in cardiovascular response to peripheral chemoreceptor stimulation in spontaneously breathing anaesthetized rats. The effects of continuous positive tracheal pressure (0.1 to 0.4 kPa) were examined in normal rats and in rats pretreated with almitrine bismesylate, a potent stimulator of the arterial chemoreceptors. In the untreated group, an increase of a maximum 4 +/- 0.7 beats.min-1 in heart rate was found during testing at pressure of 0.2 and 0.3 kPa when interference with augmented breath was avoided. These pressures at the tracheal level had no effect on systemic blood pressure, so that baroreflex influences can be discounted. During strong almitrine-induced chemostimulation, a prolonged bradycardia developed with the long-lasting hyperventilation. The same continuous positive pressures were unable to overcome the chemoreflex bradycardia. No changes in heart rate were observed under these conditions, whatever the potentiation of the mecanoreceptors for distension in the presence of alveolar hypocapnia. It was concluded that the stretching of lung mecanoreceptors on the cardiac control is of little importance in anaesthetized rats and that bradycardia generally dominates during strong stimulation of the chemoreceptors even when lung distension is artificially increased. |
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Authors:
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D Lagneaux |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives internationales de physiologie, de biochimie et de biophysique Volume: 99 ISSN: 0778-3124 ISO Abbreviation: Arch Int Physiol Biochim Biophys Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1992-03-12 Completed Date: 1992-03-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9111069 Medline TA: Arch Int Physiol Biochim Biophys Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 349-54 Citation Subset: IM; S |
Affiliation:
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Institut Léon Fredericq, Physiologie, Université de Liège, Belgique. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Almitrine
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pharmacology Animals Cardiovascular Physiological Phenomena* Chemoreceptor Cells / drug effects, physiology* Heart Rate / drug effects Lung / physiology* Male Mechanoreceptors / physiology* Pressure Rats Rats, Inbred Strains Trachea |
| Chemical | |
Reg. No./Substance:
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27469-53-0/Almitrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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