Document Detail

Interference by a non-interferon-inducing subvariant of benign encephalomyocarditis virus-B with the ability of EMCV-D to produce insulin-dependent diabetes mellitus in ICR Swiss male mice.
MedLine Citation:
PMID:  8301157     Owner:  NLM     Status:  MEDLINE    
The D variant of encephalomyocarditis virus (EMCV-D) produces a disease syndrome that mimics insulin-dependent diabetes mellitus (IDDM) in certain mouse strains. Benign EMCV-B interferes with the ability of EMCV-D to produce IDDM. Because EMCV-B induces the production of relatively large amounts of interferon (IFN), it has been hypothesized that the interference by EMCV-B with the pathogenesis of EMCV-D is due to IFN. However, we have previously reported that in outbred ICR Swiss and inbred BALB/cByJ mice, interference by EMCV-B with the development of IDDM in response to infection with EMCV-D does not appear to involve IFN. We have isolated a subvariant of EMCV-B (EMCV-B1) which, preliminary experiments indicate, does not induce the production of detectable levels of IFN in cell culture. Studies were initiated using this subvariant to determine more conclusively if IFN is involved in interference by EMCV-B with the pathogenesis of EMCV-D. The data in the present study show that EMCV-B1 does not induce the production of detectable levels of IFN either in cell culture or in mice, but retains other reported characteristics of the parent EMCV-B, including the ability to interfere with the production of IDDM by EMCV-D in ICR Swiss male mice. These observations strengthen the hypothesis that protection of pancreatic beta cells in ICR Swiss mice by EMCV-B occurs by a mechanism other than IFN.
D J Giron; S Yei
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of interferon research     Volume:  13     ISSN:  0197-8357     ISO Abbreviation:  J. Interferon Res.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-03-07     Completed Date:  1994-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100396     Medline TA:  J Interferon Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-8     Citation Subset:  IM    
Department of Microbiology and Immunology, Wright State University School of Science and Mathematics, Dayton, OH 45435.
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MeSH Terms
Diabetes Mellitus, Type 1 / microbiology*
Disease Susceptibility
Encephalomyocarditis virus / physiology*
Interferon Inducers
Mice, Inbred ICR
Reg. No./Substance:
0/Interferon Inducers

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