Document Detail


Interference: an alteRNAtive therapy following acute myocardial infarction.
MedLine Citation:
PMID:  23068432     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A complex cascade of genomic and proteomic interactions follows myocardial infarction (MI) irrespective of the intervention employed. A potential pharmacological intervention gaining momentum is RNAi therapy. RNAi therapy has been successfully clinically used in the treatment of age-related macular degeneration and cancer, but its translation to the coronary care unit is lacking despite the existence of preclinical proof of concept. Here we review current RNAi approaches and tissue-specific delivery systems that exhibit candidacy as future pharmacological interventions following MI and considerations for improved non-viral delivery to the infarcted myocardium.
Authors:
Michael Monaghan; Udo Greiser; J Gerard Wall; Timothy O'Brien; Abhay Pandit
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Trends in pharmacological sciences     Volume:  -     ISSN:  1873-3735     ISO Abbreviation:  Trends Pharmacol. Sci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906158     Medline TA:  Trends Pharmacol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Network of Excellence for Functional Biomaterials, National University of Ireland, Galway, Ireland.
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