Document Detail

Interestrous interval of cyclic gilts is decreased by systemic but not intrauterine administration of exogenous oxytocin.
MedLine Citation:
PMID:  10985415     Owner:  NLM     Status:  MEDLINE    
Oxytocin (OT) stimulates pulsatile secretion of uterine prostaglandinF2alpha in ruminants, but the role of OT in the estrous cycle regulation of pigs is not clear. These studies were performed to determine the effect of exogenous OT on interestrous interval of intact cyclic gilts. Intrauterine infusion of 80 USP units three times daily on d 10 to 16 after estrus did not decrease interestrous interval (24.5+/-1.3 d) compared with control gilts (22.5+/-1.3 d). In contrast, i.m. injections of 20 USP units of OT twice daily or 80 USP units of OT three times daily on d 10 to 16 after estrus decreased (P < 0.05) interestrous interval (20.0+/-0.3 or 19.5+/-0.4 d, respectively) compared with control gilts (20.5+/-0.3 d). When gilts received a single i.m. injection of 0 or 1 mg of estradiol valerate on d 11 and twice daily i.m. injections of 0 or 20 USP units OT on d 10 to 16 after estrus, an interaction (P = 0.05) between OT and estradiol valerate was detected. In the absence of exogenous estradiol valerate, injection of OT decreased interestrous interval (19.0+/-0.5 d) compared with injection of vehicle (20.4+/-0.5 d). However, when gilts were injected with 1 mg of estradiol valerate to inhibit luteolysis, OT did not prevent the increase in interestrous interval (25.4+/-0.5 d) compared with injections of vehicle (24.7+/-0.5 d). These results indicate that 1) exogenous OT administered by intrauterine infusion on d 10 to 16 did not decrease interestrous interval of intact cyclic gilts, 2) exogenous OT administered i.m. on d 10 to 16 shortened interestrous interval, and 3) exogenous OT did not prevent the increase in interestrous interval induced by estradiol valerate.
G L Sample; S L Kubotsu; K G Carnahan; M A Mirando
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of animal science     Volume:  78     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-19     Completed Date:  2000-12-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2393-8     Citation Subset:  IM    
Department of Animal Sciences and Center for Reproductive Biology, Washington State University, Pullman 99164-6353, USA.
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MeSH Terms
Estradiol / administration & dosage,  pharmacology
Estrus / drug effects*
Injections, Intramuscular
Least-Squares Analysis
Oxytocin / administration & dosage,  pharmacology*
Swine / metabolism*
Uterus / drug effects
Reg. No./Substance:
50-28-2/Estradiol; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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