Document Detail


Interest of flow diversion prostheses in the management of unruptured intracranial aneurysms.
MedLine Citation:
PMID:  22121490     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Flow diversion prostheses represent a new endovascular approach aimed at treating patients with large wide-neck aneurysms. Our objective is to present this new technology, to review the clinical studies on efficacy, and to emphasize its current limits. Flow diversion prostheses consist of a cylinder made of a large number of braided microfilaments providing a large metallic surface when deployed and inducing a blood flow diversion outside the aneurysm. Two different brands are currently available. Clinical data supporting their efficacy are currently limited to six non comparative cohort studies that included between 18 and 107 patients. Procedural implantation was shown to be feasible in more than 90% and safe with a thirty-day mortality between 2.8 and 5.5%. Complete occlusion rates at twelve months varied between 85.7 and 100%. Even though promising, the current status of flow diversion prostheses needs further evaluation with randomized, prospective, clinical trials with comparison to conventional strategies including endovascular coiling or surgical clipping.
Authors:
Xavier Armoiry; Mélanie Paysant; Daniel Hartmann; Gilles Aulagner; Francis Turjman
Publication Detail:
Type:  Journal Article     Date:  2011-11-03
Journal Detail:
Title:  International journal of vascular medicine     Volume:  2012     ISSN:  2090-2832     ISO Abbreviation:  Int J Vasc Med     Publication Date:  2012  
Date Detail:
Created Date:  2011-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101542608     Medline TA:  Int J Vasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  654627     Citation Subset:  -    
Affiliation:
Pharmacy Department, Groupement Hospitalier Est, Hospices Civils de Lyon, 69500 Bron, France.
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