Document Detail


Interdigitating dendritic cell sarcoma of the tonsil.
MedLine Citation:
PMID:  20887493     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare malignancy derived from antigen-presenting cells, with 55 cases reported thus far. A standard treatment modality is still being debated. This report describes a 56-year-old female who presented with right tonsillar enlargement and right submandibular swelling for 6 months. Treatment with empiric antibiotics did not result in improvement of her symptoms. Fine needle aspiration of the tonsil revealed no malignant cells. Tonsillectomy was eventually performed due to persistent symptoms. Based on microscopic findings, immunohistochemical stains, and review of the literature, the present case was finally diagnosed as IDCS of the tonsil with cervical lymph node involvement. The patient received four cycles of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy, and a clinically complete response was achieved followed by adjuvant radiation.
Authors:
Sun Young Kim; Jin-Hyoung Kang; Sang Hoon Chun; Myung Hee Chang; Yeon-Sil Kim; Sang Nam Lee; Min-Sik Kim; Chang-Suk Kang
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Asia-Pacific journal of clinical oncology     Volume:  6     ISSN:  1743-7563     ISO Abbreviation:  Asia Pac J Clin Oncol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101241430     Medline TA:  Asia Pac J Clin Oncol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  IM    
Affiliation:
Medical Oncology, The Catholic University of Korea, Seoul St Mary's Hospital, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Combined Modality Therapy
Cyclophosphamide / therapeutic use
Dendritic Cell Sarcoma, Interdigitating / metabolism,  pathology*,  therapy
Doxorubicin / therapeutic use
Female
Humans
Immunohistochemistry
Middle Aged
Prednisone / therapeutic use
Radiotherapy, Adjuvant
Tonsillar Neoplasms / metabolism,  pathology*,  therapy
Tonsillectomy
Vincristine / therapeutic use
Chemical
Reg. No./Substance:
23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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