Document Detail


Interdigitating dendritic cell sarcoma of the parotid gland: case report and literature review.
MedLine Citation:
PMID:  19563939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interdigitating dendritic cell sarcoma (IDCS) is an exceedingly rare neoplasm arising from the antigen-presenting cells of the immune system. We report a case of IDCS occurring in a 69-year-old man who presented to an outside institution with a painless mass in his right parotid gland for several months. He presented to our institution after undergoing a superficial parotidectomy. A diagnosis of undifferentiated neoplasm, favoring poorly differentiated carcinoma, was made at that time. He underwent a total parotidectomy and neck dissection at our institution. Microscopically, the tumor was composed of atypical spindle cells involving the parotid gland and an ipsilateral level III lymph node. Immunophenotypic analysis demonstrated positive staining for S100, fascin, vimentin, and HLA-II. Follicular dendritic cell, lymphoid, epithelial, myoepithelial, and melanoma markers were negative. Taken together, the above features were consistent with IDCS. An IDCS of the parotid gland is extremely rare, with only 2 cases reported in the literature. The unusual location and morphological similarity to follicular dendritic sarcoma and other types of soft tissue sarcomas can be a diagnostic challenge. Awareness of this tumor and the use of appropriate markers are crucial in making the diagnosis. The patient did well postoperatively, and he underwent a complete course of postoperative irradiation to the right parotid and neck.
Authors:
Guy Efune; Baran D Sumer; Venetia R Sarode; Huan-You Wang; Larry L Myers
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-10-01
Journal Detail:
Title:  American journal of otolaryngology     Volume:  30     ISSN:  1532-818X     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  264-8     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9035, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biopsy, Fine-Needle
Dendritic Cell Sarcoma, Interdigitating / diagnosis*,  surgery
Diagnosis, Differential
Follow-Up Studies
Humans
Male
Oral Surgical Procedures / methods
Parotid Neoplasms / diagnosis*,  surgery
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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