Document Detail


An interdependent model of central/peripheral chemoreception: evidence and implications for ventilatory control.
MedLine Citation:
PMID:  20206717     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this review we discuss the implications for ventilatory control of newer evidence suggesting that central and peripheral chemoreceptors are not functionally separate but rather that they are dependent upon one another such that the sensitivity of the medullary chemoreceptors is critically determined by input from the carotid body chemoreceptors and vice versa i.e., they are interdependent. We examine potential interactions of the interdependent central and carotid body (CB) chemoreceptors with other ventilatory-related inputs such as central hypoxia, lung stretch, and exercise. The limitations of current approaches addressing this question are discussed and future studies are suggested.
Authors:
Curtis A Smith; Hubert V Forster; Grégory M Blain; Jerome A Dempsey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2010-03-04
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  173     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-25     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  288-97     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA. casmith4@wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / cytology,  physiology*
Carotid Body / cytology,  metabolism*
Chemoreceptor Cells / cytology,  metabolism*
Humans
Models, Biological*
Pulmonary Ventilation / physiology*
Grant Support
ID/Acronym/Agency:
HL 15469/HL/NHLBI NIH HHS; HL 25739/HL/NHLBI NIH HHS; HL 50531/HL/NHLBI NIH HHS; R01 HL015469-36/HL/NHLBI NIH HHS
Comments/Corrections

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