| Intercenter differences in diffusion tensor MRI acquisition. | |
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MedLine Citation:
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PMID: 20512899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess the effect on diffusion tensor (DT) magnetic resonance imaging (MRI) of acquiring data with different scanners. MATERIALS AND METHODS: Forty-four healthy controls and 36 multiple sclerosis patients with low disability were studied using eight MR scanners with acquisition protocols that were as close to a standard protocol as possible. Between 7 and 13 subjects were studied in each center. Region-of-interest (ROI) and histogram-based analyses of fractional anisotropy (FA), axial (D(ax)), radial (D(rad)), and mean diffusivity (MD) were performed. The influence of variables such as the acquisition center and the control/patient group was determined with an analysis of variance (ANOVA) test. RESULTS: The patient/control group explained approximately 25% of data variability of FA and D(rad) from midsagittal corpus callosum (CC) ROIs. Global FA, MD, and D(rad) in the white matter differentiated patients from controls, but with lower discriminatory power than for the CC. In the gray matter, MD discriminated patients from controls (30% of variability explained by group vs. 17% by center). CONCLUSION: Significant variability of DT-MRI data can be attributed to the acquisition center, even when a standardized protocol is used. The use of appropriate segmentation methods and statistical models allows DT-derived metrics to differentiate patients from healthy controls. |
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Authors:
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Elisabetta Pagani; Jochen G Hirsch; Petra J W Pouwels; Mark A Horsfield; Elisabetta Perego; Achim Gass; Stefan D Roosendaal; Frederik Barkhof; Federica Agosta; Marco Rovaris; Domenico Caputo; Antonio Giorgio; Jacqueline Palace; Silvia Marino; Nicola De Stefano; Stefan Ropele; Franz Fazekas; Massimo Filippi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 31 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1458-68 Citation Subset: IM |
Affiliation:
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Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, 20132 Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Corpus Callosum / pathology* Diffusion Diffusion Magnetic Resonance Imaging / methods* Female Humans Image Processing, Computer-Assisted Male Middle Aged Multiple Sclerosis / diagnosis*, pathology* Prospective Studies Reproducibility of Results Water / chemistry |
| Chemical | |
Reg. No./Substance:
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7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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