Document Detail

Intercellular pathway of leucine catabolism in rat spermatogenic epithelium.
MedLine Citation:
PMID:  3985949     Owner:  NLM     Status:  MEDLINE    
A unique intercellular pathway of leucine catabolism was observed in vitro in rat spermatogenic epithelium. Sertoli cells convert leucine via transmination into 4-methyl-2-oxovalerate, and spermatocytes and spermatids reduce exogenous 4-methyl-2-oxovalerate to 2-hydroxy-4-methylvalerate, which is then released by the spermatogenic cells. The NADH-dependent reduction of 4-methyl-2-oxovalerate could be catalysed by the male-germ-cell-specific lactate dehydrogenase isoenzyme LDH-C4 in the cytosol of the spermatogenic cells, concomitant with the NAD+-dependent conversion of exogenous lactate into pyruvate.
J A Grootegoed; R Jansen; H J van der Molen
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  226     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-05-23     Completed Date:  1985-05-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  889-92     Citation Subset:  IM    
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MeSH Terms
Chromatography, Gas
Epithelium / metabolism
Extracellular Space / metabolism
Keto Acids / metabolism
Leucine / metabolism*
Rats, Inbred Strains
Sertoli Cells / metabolism
Testis / metabolism*
Reg. No./Substance:
0/Keto Acids; 61-90-5/Leucine; 816-66-0/alpha-ketoisocaproic acid

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