| Intercellular pathway of leucine catabolism in rat spermatogenic epithelium. | |
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MedLine Citation:
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PMID: 3985949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A unique intercellular pathway of leucine catabolism was observed in vitro in rat spermatogenic epithelium. Sertoli cells convert leucine via transmination into 4-methyl-2-oxovalerate, and spermatocytes and spermatids reduce exogenous 4-methyl-2-oxovalerate to 2-hydroxy-4-methylvalerate, which is then released by the spermatogenic cells. The NADH-dependent reduction of 4-methyl-2-oxovalerate could be catalysed by the male-germ-cell-specific lactate dehydrogenase isoenzyme LDH-C4 in the cytosol of the spermatogenic cells, concomitant with the NAD+-dependent conversion of exogenous lactate into pyruvate. |
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Authors:
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J A Grootegoed; R Jansen; H J van der Molen |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 226 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-05-23 Completed Date: 1985-05-23 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 889-92 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, Gas Epithelium / metabolism Extracellular Space / metabolism Keto Acids / metabolism Leucine / metabolism* Male Rats Rats, Inbred Strains Sertoli Cells / metabolism Spermatogenesis* Testis / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Keto Acids; 61-90-5/Leucine; 816-66-0/alpha-ketoisocaproic acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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