Document Detail

Intercellular communication: diverse structures for exchange of genetic information.
MedLine Citation:
PMID:  22510790     Owner:  NLM     Status:  MEDLINE    
An emerging concept is that cellular communication in mammals can be mediated by the exchange of genetic information, mainly in the form of microRNAs. This can occur when extracellular vesicles, such as exosomes, secreted by a donor cell are taken up by an acceptor cell. Transfer of genetic material can also occur through intimate membrane contacts between donor and acceptor cells. Specialized cell-cell contacts, such as synapses, have the potential to combine these modes of genetic transfer.
Maria Mittelbrunn; Francisco Sánchez-Madrid
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-18
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  13     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-06-08     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  328-35     Citation Subset:  IM    
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MeSH Terms
Biological Transport
Cell Communication*
Cell-Derived Microparticles / metabolism
RNA / genetics,  metabolism*
RNA Interference*
Synapses / metabolism
Grant Support
294340//European Research Council
Reg. No./Substance:

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