| Intercellular transport of microRNAs. | |
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MedLine Citation:
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PMID: 23325475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracellular microRNAs (miRNA) are present in most biological fluids, relatively stable, and hold great potential for disease biomarkers and novel therapeutics. Circulating miRNAs are transported by membrane-derived vesicles (exosomes and microparticles), lipoproteins, and other ribonucleoprotein complexes. Evidence suggests that miRNAs are selectively exported from cells with distinct signatures that have been found to be altered in many pathophysiologies, including cardiovascular disease. Protected from plasma ribonucleases by their carriers, functional miRNAs are delivered to recipient cells by various routes. Transferred miRNAs use cellular machinery to reduce target gene expression and alter cellular phenotype. Similar to soluble factors, miRNAs mediate cell-to-cell communication linking disparate cell types, diverse biological mechanisms, and homeostatic pathways. Although significant advances have been made, miRNA intercellular communication is full of complexities and many questions remain. This review brings into focus what is currently known and outstanding in a novel field of study with applicability to cardiovascular disease. |
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Authors:
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Reinier A Boon; Kasey C Vickers |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 33 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-17 Completed Date: 2013-03-14 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 186-92 Citation Subset: IM |
Affiliation:
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Institute for Cardiovascular Regeneration, J.W. Goethe University Hospital, Frankfurt am Main, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Cardiovascular Diseases / genetics, metabolism Cell Communication Cell-Derived Microparticles / metabolism Exosomes / metabolism Gene Expression Regulation Genotype Humans Lipoproteins / metabolism MicroRNAs / blood, metabolism* Phenotype RNA Stability Ribonucleoproteins / metabolism Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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K22HL113039/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins; 0/MicroRNAs; 0/Ribonucleoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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