Document Detail


Intercellular transport of microRNAs.
MedLine Citation:
PMID:  23325475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extracellular microRNAs (miRNA) are present in most biological fluids, relatively stable, and hold great potential for disease biomarkers and novel therapeutics. Circulating miRNAs are transported by membrane-derived vesicles (exosomes and microparticles), lipoproteins, and other ribonucleoprotein complexes. Evidence suggests that miRNAs are selectively exported from cells with distinct signatures that have been found to be altered in many pathophysiologies, including cardiovascular disease. Protected from plasma ribonucleases by their carriers, functional miRNAs are delivered to recipient cells by various routes. Transferred miRNAs use cellular machinery to reduce target gene expression and alter cellular phenotype. Similar to soluble factors, miRNAs mediate cell-to-cell communication linking disparate cell types, diverse biological mechanisms, and homeostatic pathways. Although significant advances have been made, miRNA intercellular communication is full of complexities and many questions remain. This review brings into focus what is currently known and outstanding in a novel field of study with applicability to cardiovascular disease.
Authors:
Reinier A Boon; Kasey C Vickers
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  33     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-03-14     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  186-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Cardiovascular Diseases / genetics,  metabolism
Cell Communication
Cell-Derived Microparticles / metabolism
Exosomes / metabolism
Gene Expression Regulation
Genotype
Humans
Lipoproteins / metabolism
MicroRNAs / blood,  metabolism*
Phenotype
RNA Stability
Ribonucleoproteins / metabolism
Signal Transduction
Grant Support
ID/Acronym/Agency:
K22HL113039/HL/NHLBI NIH HHS; Z99 HL999999/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Lipoproteins; 0/MicroRNAs; 0/Ribonucleoproteins
Comments/Corrections

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