| Intercellular adhesion molecule-1 (ICAM-1) is upregulated in aggressive papillary thyroid carcinoma. | |
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MedLine Citation:
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PMID: 21879273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Intercellular adhesion molecule-1 (ICAM-1) is implicated in carcinogenesis. In this study we examined the expression of ICAM-1 in papillary thyroid cancer (PTC). We hypothesized that ICAM-1 correlates with indicators of tumor aggressiveness in PTC. METHODS: Thirty-five primary and metastatic PTCs, five follicular adenomas, five Hashimoto thyroiditis, five nodular hyperplasia, and eight normal thyroid tissue samples were analyzed for ICAM-1 gene expression using quantitative reverse-transcription polymerase chain reaction (RT-PCR). ICAM-1 gene expression was analyzed at protein level by immunohistochemistry (IHC) using a semiquantitative score. Gene expression and intensity levels were correlated with markers of tumor aggressiveness including BRAF V600E mutation, tumor size, extrathyroidal extension (ETE), angiolymphatic invasion, and lymph node metastasis. RESULTS: ICAM-1 gene expression was higher in PTC (p = 0.01) and lymph node metastases (p = 0.03) when compared with benign tumors and Hashimoto's. Furthermore, PTCs exhibiting BRAF V600E mutation (p = 0.01), ETE (p < 0.01), and lymph node metastasis (p = 0.02) were associated with higher ICAM-1 levels. Gene expression correlated with protein levels on IHC. Additionally, poorly differentiated thyroid carcinoma had a higher ICAM-1 intensity score compared with well-differentiated carcinoma (p = 0.03). CONCLUSIONS: ICAM-1 expression is upregulated in papillary thyroid carcinoma. Furthermore, ICAM-1 upregulation correlated with aggressive tumor features such as BRAF V600E mutation, ETE, and lymph node metastasis, suggesting that ICAM-1 plays a role in thyroid cancer progression. |
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Authors:
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D Buitrago; X M Keutgen; M Crowley; F Filicori; H Aldailami; R Hoda; Yi-Fang Liu; R S Hoda; T Scognamiglio; M Jin; T J Fahey; R Zarnegar |
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Publication Detail:
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Type: Journal Article Date: 2011-08-31 |
Journal Detail:
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Title: Annals of surgical oncology Volume: 19 ISSN: 1534-4681 ISO Abbreviation: Ann. Surg. Oncol. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-21 Completed Date: 2012-06-12 Revised Date: 2012-06-21 |
Medline Journal Info:
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Nlm Unique ID: 9420840 Medline TA: Ann Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 973-80 Citation Subset: IM |
Affiliation:
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Division of Endocrine and Minimally Invasive Surgery, Department of Surgery, New York Presbyterian Hospital-Weill Cornell Medical College, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Carcinoma, Papillary / genetics, metabolism*, pathology Female Gene Expression Regulation, Neoplastic* Hashimoto Disease / genetics, metabolism Humans Intercellular Adhesion Molecule-1 / genetics, metabolism* Lymphatic Metastasis Male Middle Aged Mutation Protein Array Analysis Proto-Oncogene Proteins B-raf / genetics Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Thyroid Neoplasms / genetics, metabolism*, pathology Up-Regulation* Young Adult |
| Chemical | |
Reg. No./Substance:
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126547-89-5/Intercellular Adhesion Molecule-1; EC 2.7.11.1/BRAF protein, human; EC 2.7.11.1/Proto-Oncogene Proteins B-raf |
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