Document Detail


Intercalation of amino acids and peptides into Mg-Al layered double hydroxide by reconstruction method.
MedLine Citation:
PMID:  14706258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intercalation of amino acids and some peptides into Mg-Al layered double hydroxide known as hydrotalcite was examined. Although the intercalation by ion-exchange method was unsuccessful, all the amino acids except for Lys and Arg, and peptides examined could be intercalated into the layered double hydroxide by reconstruction method using Mg-Al oxide precursor. The uptake amounts of amino acids and peptides were 0.9-2.7 mmol per 1 g of LDH. Intercalation compounds were examined by using XRD and solid-state NMR. For Gly, Ala, Ser, Thr, Pro, Asn, Gln, Asp, Glu, and aspartame the intercalation accompanied the expansion of interlayer distance of the solid products, whereas the other amino acids and oligoglycine showed no expansion. The intercalation mechanism and release profile in K(2)CO(3) aqueous solution were also investigated. And the cointercalation of amino acids and peptides into Mg-Al LDH and easy release of amino acids from the LDH layer were found.
Authors:
Hirokazu Nakayama; Natsuko Wada; Mitsutomo Tsuhako
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  269     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-06     Completed Date:  2004-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  469-78     Citation Subset:  IM    
Affiliation:
Department of Functional Molecular Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan. hiro@kobepharma-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aluminum Hydroxide / chemistry*
Amino Acids / chemistry*
Antacids / chemistry*
Aspartame / chemistry
Chemistry, Pharmaceutical / methods*
Dipeptides / chemistry
Glycine / chemistry
Intercalating Agents / chemistry*
Magnesium Hydroxide / chemistry*
X-Ray Diffraction
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Antacids; 0/Dipeptides; 0/Intercalating Agents; 12304-65-3/hydrotalcite; 1309-42-8/Magnesium Hydroxide; 21645-51-2/Aluminum Hydroxide; 22839-47-0/Aspartame; 56-40-6/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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