Document Detail


Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers.
MedLine Citation:
PMID:  1536845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pressure versus fluid spacing relations have been obtained for sphingomyelin bilayers in the gel phase and equimolar sphingomyelin/cholesterol in the liquid-crystalline phase by the use of X-ray diffraction analysis of osmotically stressed aqueous dispersions and oriented multilayers. For interbilayer separations in the range of 5-20 A, the repulsive hydration pressure decays exponentially with increasing fluid spacing. The decay length (lambda) of this repulsive pressure is about 2 A for both bovine brain and N-tetracosanoylsphingomyelin, similar to that previously found for phosphatidylcholine bilayers. However, both the magnitude of the hydration pressure and the magnitude of the dipole potential (V) measured for monolayers in equilibrium with liposomes are considerably smaller for sphingomyelin than for either gel or liquid-crystalline phosphatidylcholine bilayers. Addition of equimolar cholesterol increases both the magnitude of the hydration pressure and the dipole potential. These data suggest that the magnitude of the hydration pressure depends on the electric field at the interface as given by (V/lambda)2. For sphingomyelin bilayers, there is a sharp upward break in the pressure-fluid spacing relation at an interbilayer spacing of about 5 A, indicating the onset of steric hindrance between the head groups of apposing bilayers.
Authors:
T J McIntosh; S A Simon; D Needham; C H Huang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemistry     Volume:  31     ISSN:  0006-2960     ISO Abbreviation:  Biochemistry     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-30     Completed Date:  1992-03-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370623     Medline TA:  Biochemistry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2020-4     Citation Subset:  IM    
Affiliation:
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Chemistry
Cattle
Cholesterol / chemistry*
Electrons
Lipid Bilayers*
Phosphatidylcholines / chemistry
Sphingomyelins / chemistry*
X-Ray Diffraction
Grant Support
ID/Acronym/Agency:
GM-27278/GM/NIGMS NIH HHS; GM-40162/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Lipid Bilayers; 0/Phosphatidylcholines; 0/Sphingomyelins; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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