Document Detail


Interactive effects of saffron with garlic and curcumin against cyclophosphamide induced genotoxicity in mice.
MedLine Citation:
PMID:  15331343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Saffron is a well-known spice and food colorant commonly consumed in different parts of the world. Recently, much attention has been focused on the biological and medicinal properties of saffron. In the present study the interactive effects of saffron with two commonly consumed dietary agents, garlic and curcumin was evaluated for anti-genotoxic effects against cyclophosphamide (CPH) in the mouse bone marrow micronucleus test. Experimental animals were orally pretreated with saffron (100 mg/kg body weight), garlic (250 mg/kg body weight) and curcumin (10 mg/kg body weight), either alone or in combination for five consecutive days, 2h prior to the administration of CPH. Maximum reduction in the frequencies of micronucleated polychromatic erythrocytes (Mn PCEs) induced by CPH was observed when all the three test compounds were administered together. Furthermore, the protective effects were more pronounced in the garlic-administered groups compared to curcumin and/or saffron administered groups.
Authors:
Kumpati Premkumar; Sundramoorthy Kavitha; Sathiyavedu T Santhiya; A-Rabandi Ramesh; Jiraporn Suwanteerangkul
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Asia Pacific journal of clinical nutrition     Volume:  13     ISSN:  0964-7058     ISO Abbreviation:  Asia Pac J Clin Nutr     Publication Date:  2004  
Date Detail:
Created Date:  2004-08-27     Completed Date:  2005-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9440304     Medline TA:  Asia Pac J Clin Nutr     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  292-4     Citation Subset:  IM    
Affiliation:
Department of Genetics, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras,Taramani, Chennai 600-113, India. pkumpati@yahoo.co.in
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Antimutagenic Agents / pharmacology*
Chromosome Aberrations / drug effects*
Crocus / chemistry*
Curcumin / chemistry*
Cyclophosphamide / administration & dosage
Drug Combinations
Garlic / chemistry*
Male
Mice
Micronucleus Tests
Mutagens / administration & dosage
Plant Extracts / pharmacology*
Chemical
Reg. No./Substance:
0/Antimutagenic Agents; 0/Drug Combinations; 0/Mutagens; 0/Plant Extracts; 458-37-7/Curcumin; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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