Document Detail

Interactive effects of physostigmine and exercise on cholinesterase activity in red blood cells and tissues of rat.
MedLine Citation:
PMID:  2095716     Owner:  NLM     Status:  MEDLINE    
Physostigmine is considered to be a potential pretreatment agent against organophosphate intoxication. This investigation elicits the effects of three intensities of acute exercise (50, 80 and 100% VO2max), administration of physostigmine (70 micrograms/kg, i.m.) and the combined effect of physostigmine and three intensities of acute exercise on cholinesterase activity in red blood cells and various tissues and endurance time in rats. The cholinesterase activity in red blood cells in exercised rats not exposed to physostigmine was significantly greater than that of unexercised controls (116, 112 and 108% of control, p less than 0.05, at 50, 80 and 100% VO2max, respectively) while in other tissues the cholinesterase activity in general decreased slightly. In unexercised rats given physostigmine, the cholinesterase activity ranges were 73-79, 66-68, 68-74, 67-81 and 57-61% of controls from 10-30 min in red blood cells, brain, heart, diaphragm and thigh muscle, respectively. In exercised rats exposed to physostigmine, the cholinesterase activity ranges were 54-51, 58-50, 77-73, 71-83 and 54-58% of controls from 10-30 min in red blood cells, brain, heart, diaphragm and thigh muscle, respectively. The results indicate that in control rats not given physostigmine, different intensities of acute exercise affect the cholinesterase enzyme to a moderate degree in red blood cells (p less than 0.05) and heart (p less than 0.05) without affecting brain, diaphragm and thigh muscle. Acute exercise modifies the effect of physostigmine significantly (p less than 0.01) by increasing the cholinesterase inhibition in red blood cells and brain without affecting other tissues. Exposure of rats to physostigmine (70 micrograms/kg, i.m.) increases the endurance time in rats (160-200 g weight), possibly due to peripheral vasodilatation and lowering of core temperature.
S N Dube; S M Somani; J A Colliver
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  307     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1991-07-08     Completed Date:  1991-07-08     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  71-82     Citation Subset:  IM; S    
Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield 62794-9230.
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MeSH Terms
Brain / drug effects,  enzymology
Cholinesterases / blood,  metabolism*
Erythrocytes / enzymology*
Heart / drug effects
Muscles / drug effects,  enzymology
Myocardium / enzymology
Oxygen Consumption / drug effects
Physical Conditioning, Animal*
Physical Endurance / drug effects
Physostigmine / pharmacology*
Rats, Inbred Strains
Respiratory Muscles / drug effects,  enzymology
Reg. No./Substance:
57-47-6/Physostigmine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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