Document Detail

Interactive effects of antioxidant genes and air pollution on respiratory function and airway disease: a HuGE review.
MedLine Citation:
PMID:  21343247     Owner:  NLM     Status:  MEDLINE    
Susceptibility to the respiratory effects of air pollution varies between individuals. Although some evidence suggests higher susceptibility for subjects carrying variants of antioxidant genes, findings from gene-pollution interaction studies conflict in terms of the presence and direction of interactions. The authors conducted a systematic review on antioxidant gene-pollution interactions which included 15 studies, with 12 supporting the presence of interactions. For the glutathione S-transferase M1 gene (GSTM1) (n=10 studies), only 1 study found interaction with the null genotype alone, although 5 observed interactions when GSTM1 was evaluated jointly with other genes (mainly NAD(P)H dehydrogenase [quinone] 1 (NQO1)). All studies on the glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism (n=11) provided some evidence of interaction, but findings conflicted in terms of risk allele. Results were negative for glutathione S-transferase T1 (GSTT1) (n=3) and positive for heme oxygenase 1 (HMOX-1) (n=2). Meta-analysis could not be performed because there were insufficient data available for any specific gene-pollutant-outcome combination. Overall the evidence supports the presence of gene-pollution interactions, although which pollutant interacts with which gene is unclear. However, issues regarding multiple testing, selective reporting, and publication bias raise the possibility of false-positive findings. Larger studies with greater accuracy of pollution assessment and improved quality of conduct and reporting are required.
Cosetta Minelli; Igor Wei; Gurdeep Sagoo; Debbie Jarvis; Seif Shaheen; Peter Burney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-02-22
Journal Detail:
Title:  American journal of epidemiology     Volume:  173     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-09     Completed Date:  2011-05-11     Revised Date:  2012-05-28    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  603-20     Citation Subset:  IM    
Copyright Information:
© The Author 2011. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
Institute of Genetic Medicine, EURAC Research, Viale Druso 1, 39100 Bolzano, Italy.
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MeSH Terms
Air Pollution / adverse effects*
Antioxidants / metabolism
Genetic Predisposition to Disease / etiology,  genetics*
Glutathione S-Transferase pi / genetics*
Glutathione Transferase / genetics*
Heme Oxygenase-1 / genetics*
NAD(P)H Dehydrogenase (Quinone) / genetics*
Oxidative Stress / drug effects,  genetics
Respiratory System / drug effects*,  physiopathology
Respiratory Tract Diseases / etiology,  genetics*,  physiopathology
Grant Support
//Department of Health
Reg. No./Substance:
0/Antioxidants; EC protein, human; EC Oxygenase-1; EC Dehydrogenase (Quinone); EC protein, human; EC protein, human; EC S-Transferase pi; EC Transferase; EC S-transferase M1

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