Document Detail


Interactive effects of antioxidant genes and air pollution on respiratory function and airway disease: a HuGE review.
MedLine Citation:
PMID:  21343247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Susceptibility to the respiratory effects of air pollution varies between individuals. Although some evidence suggests higher susceptibility for subjects carrying variants of antioxidant genes, findings from gene-pollution interaction studies conflict in terms of the presence and direction of interactions. The authors conducted a systematic review on antioxidant gene-pollution interactions which included 15 studies, with 12 supporting the presence of interactions. For the glutathione S-transferase M1 gene (GSTM1) (n=10 studies), only 1 study found interaction with the null genotype alone, although 5 observed interactions when GSTM1 was evaluated jointly with other genes (mainly NAD(P)H dehydrogenase [quinone] 1 (NQO1)). All studies on the glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism (n=11) provided some evidence of interaction, but findings conflicted in terms of risk allele. Results were negative for glutathione S-transferase T1 (GSTT1) (n=3) and positive for heme oxygenase 1 (HMOX-1) (n=2). Meta-analysis could not be performed because there were insufficient data available for any specific gene-pollutant-outcome combination. Overall the evidence supports the presence of gene-pollution interactions, although which pollutant interacts with which gene is unclear. However, issues regarding multiple testing, selective reporting, and publication bias raise the possibility of false-positive findings. Larger studies with greater accuracy of pollution assessment and improved quality of conduct and reporting are required.
Authors:
Cosetta Minelli; Igor Wei; Gurdeep Sagoo; Debbie Jarvis; Seif Shaheen; Peter Burney
Related Documents :
16775367 - Molecular genetics of autosomal-dominant axonal charcot-marie-tooth disease.
20221787 - Lactoferrin: the path from protein to gene.
22165947 - Mining the gene wiki for functional genomic knowledge.
22544717 - A small number of genes underlie male pigmentation traits in lake malawi cichlid fishes.
21765177 - Global analysis of expression profiles of rice receptor-like kinase genes.
9671577 - The development of apical embryonic pattern in arabidopsis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-02-22
Journal Detail:
Title:  American journal of epidemiology     Volume:  173     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-09     Completed Date:  2011-05-11     Revised Date:  2012-05-28    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  603-20     Citation Subset:  IM    
Copyright Information:
© The Author 2011. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
Affiliation:
Institute of Genetic Medicine, EURAC Research, Viale Druso 1, 39100 Bolzano, Italy. cosetta.minelli@eurac.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Air Pollution / adverse effects*
Antioxidants / metabolism
Child
Female
Genetic Predisposition to Disease / etiology,  genetics*
Genotype
Glutathione S-Transferase pi / genetics*
Glutathione Transferase / genetics*
Heme Oxygenase-1 / genetics*
Humans
Infant
Male
NAD(P)H Dehydrogenase (Quinone) / genetics*
Oxidative Stress / drug effects,  genetics
Respiratory System / drug effects*,  physiopathology
Respiratory Tract Diseases / etiology,  genetics*,  physiopathology
Grant Support
ID/Acronym/Agency:
//Department of Health
Chemical
Reg. No./Substance:
0/Antioxidants; EC 1.14.99.3/HMOX1 protein, human; EC 1.14.99.3/Heme Oxygenase-1; EC 1.6.5.2/NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2/NQO1 protein, human; EC 2.5.1.18/GSTP1 protein, human; EC 2.5.1.18/Glutathione S-Transferase pi; EC 2.5.1.18/Glutathione Transferase; EC 2.5.1.18/glutathione S-transferase M1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Improving Public Health Surveillance Using a Dual-Frame Survey of Landline and Cell Phone Numbers.
Next Document:  Multivitamin use and the risk of mortality and cancer incidence: the multiethnic cohort study.