Document Detail


Interactive effects of APOE haplotype, sex, and exercise on postheparin plasma lipase activities.
MedLine Citation:
PMID:  21252218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatic lipase (HL) and lipoprotein lipase (LPL) activities (HLA, LPLA) modify lipoproteins and facilitate their binding to hepatic receptors. Apolipoprotein E (APOE) physically interacts with the lipases, and the three common haplotypes of the APOE gene (ε2, ε3, and ε4) yield protein isoforms (E2, E3, and E4, respectively) that are functionally different. Lipase activities themselves differ by sex and exercise training status. The interaction of APOE genotype, exercise training, and sex effects on lipase activities has not been studied. We measured postheparin plasma lipase activities in normolipidemic men and women with the three most common APOE genotypes, which are the haplotype combinations ε2/ε3 (n = 53 ), ε3/ε3 (n = 62), and ε4/ε3 (n = 52), enrolled in 6 mo of aerobic exercise training. These haplotype combinations comprise an estimated 11.6, 62.3, and 21.3% of the population, respectively. Baseline HLA was 35% lower in women than in men (P < 0.0001). In men but not women, HLA was higher in ε2/ε3 group compared with ε4/ε3 (P = 0.01) and ε3/ε3 (P = 0.05). Neither sex nor APOE genotype affected baseline LPLA. Training decreased HLA by 5.2% (P = 0.018) with no APOE effect. The apparent increase in LPLA following exercise was significant and APOE dependent only when corrected for baseline insulin (P < 0.05). Exercise decreased LPLA by 0.8 μmol free fatty acid (FFA)·ml⁻¹·h⁻¹ (-6%) in ε3/ε3 compared with the combined increases of 6.6% in ε2/ε3 and 12% in ε4/ε3 (P = 0.018 vs. ε3/ε3). However, these differences were statistically significant only after correcting for baseline insulin. We conclude that common APOE genotypes interact with 1) sex to modulate HLA regardless of training status, with ε2/ε3 men demonstrating higher HLA than ε3/ε3 or ε4/ε3 men, and 2) aerobic training to modulate LPLA, regardless of sex, with ε3/ε3 subjects showing a significant decrease compared with an increase in ε2/ε3 and ε3/ε4 after controlling for baseline insulin.
Authors:
Richard L Seip; Robert F Zoeller; Theodore J Angelopoulos; James Salonia; Cherie Bilbie; Niall M Moyna; Mary P Miles; Paul S Visich; Linda S Pescatello; Paul M Gordon; Gregory J Tsongalis; Linda Bausserman; Paul D Thompson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-20
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  110     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-13     Completed Date:  2011-08-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1021-8     Citation Subset:  IM    
Affiliation:
Preventive Cardiology-JB704, Hartford Hospital, Hartford, CT 06102-5037, USA. rseip@harthosp.org
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Apolipoproteins E / blood,  genetics*
Exercise / physiology*
Female
Genotype
Haplotypes
Humans
Insulin / blood
Lipids / blood
Lipoprotein Lipase / blood*,  genetics
Male
Risk Factors
Sex Factors
Grant Support
ID/Acronym/Agency:
1 R15 AG13767-01A1/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Insulin; 0/Lipids; EC 3.1.1.34/Lipoprotein Lipase
Comments/Corrections

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